69323-67-7

Upstream product

• 66026-10-6 N-((4aR,6S,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)acetamide 
• 7474-05-7 (R)-2-chloropropionic acid 
• 3006-58-4 2-carbobenzyloxyamino-2-deoxy-D-glucopyranose 
• 29617-66-1 (S)-2-chloropropanoic acid 
• 75263-30-8 benzyl 2-acetamido-2-deoxy-4,6-isopropylidene-α-D-allopyranosidede 
• 75263-33-1 benzyl 2-acetamido-2-deoxy-4,6-O-isopropylidene-α-D-galactopyranoside 
• 75263-31-9 benzyl 2-acetamido-2-deoxy-4,6-O-isopropylidene-α-D-gulopyranoside 
• 50605-12-4 benzyl 2-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside 
• 598-78-7 L-2-chloropropionic acid 
• 33423-30-2 benzyl 2-acetamido-2-deoxy-α-D-gulopyranoside 
• 3554-93-6 benzyl 2-acetamido-2-deoxy-α-D-galactopyranoside 
• 75263-24-0 benzyl 2-acetamido-2-deoxy-4,6-isopropylidene-3-O-mesyl-α-D-glucopyranoside 
• 7512-17-6 N-Acetyl-D-glucosamine 
• 100-51-6 benzyl alcohol 

Downstream Products

• 69323-69-9 N-<2-O-(benzyl 2-acetamido-2,3-dideoxy-4,6-O-isopropylidene-β-D-glucopyranosid-3-yl)-D-lactoyl>-L-alanyl-D-isoglutamine benzyl ester 
• 57816-11-2 N-<2-O-(benzyl 2-acetamido-2,3-dideoxy-β-D-glucopyranosid-3-yl)-D-lactoyl>-L-alanyl-D-isoglutamine benzyl ester 
• 128726-61-4 N-<2-O-(benzyl 2-acetamido-6-O-< 5-(tert-butoxycarbonylamino)pentanoyl>-2,3-dideoxy-β-D-glucopyranosid-3-yl)-D-lactoyl>-L-alanyl-D-isoglutamine benzyl ester 
• 128747-59-1 N-<2-O-(benzyl 2-acetamido-6-O-< 8-(tert-butoxycarbonylamino)octanoyl>-2,3-dideoxy-β-D-glucopyranosid-3-yl)-D-lactoyl>-L-alanyl-D-isoglutamine benzyl ester 
• 128747-55-7 N-(2-O--D-lactoyl)-L-alanyl-D-isoglutamine benzyl ester trifluoroacetate 
• 128726-70-5 N-(2-O--D-lactoyl)-L-alanyl-D-isoglutamine benzyl ester trifluoroacetate 
• 79957-36-1 benzyl 2-acetamido-4,6-di-O-acetyl-2-deoxy-3-O--α-D-galactopyranoside 
• 62928-83-0 benzyl (R)-4-((S)-2-((R)-2-(((2S,3R,4R,5S,6R)-3-acetamido-2-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)propanamido)propanamido)-5-amino-5-oxopentanoate 
• 69323-69-9 benzyl (R)-4-((S)-2-((R)-2-(((4aR,6S,7R,8R,8aS)-7-acetamido-6-(benzyloxy)-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-8-yl)oxy)propanamido)propanamido)-5-amino-5-oxopentanoate 
• 129392-11-6 Benzyl 2-Acetamido-4-O-acetyl-2-deoxy-3-O-<(R)-1-(ethoxycarbonyl)ethyl>-α-D-glucopyranosiduronic Acid Benzyl Ester 
• 129392-06-9 Benzyl 2-Acetamido-4-O-acetyl-3-O-<(R)-1-carbamoylethyl>-2-deoxy-α-D-glucopyranosiduronic Acid Benzyl Ester 
• 129392-10-5 Benzyl 2-Acetamido-2-deoxy-3-O-<(R)-1-(methoxycarbonyl))ethyl>-α-D-glucopyranosiduronic Acid Benzyl ester 
• 129392-05-8 Benzyl 2-Acetamido-3-O-<(R)-1-carbamoylethyl>-2-deoxy-α-D-glucopyranosiduronic Acid Benzyl ester 
• 129392-08-1 2-Acetamido-4-O-acetyl-2-deoxy-3-O-<(R)-1-(methoxycarbonyl)ethyl>-D-glucopyranosiduronic Acid Benzyl Ester 

Relevant academic research and scientific papers

Convergent synthesis of novel muramyl dipeptide analogues: Inhibition of porphyromonas gingivalis-induced pro-inflammatory effects by high doses of muramyl dipeptide

Porphyromonas gingivalis (P.g.)-induced TNF-α can be affected by muramyl dipeptide (MDP) in a biphasic concentration-dependent manner. We found that in P.g.-exposed macrophages, treatment with 10 μg/mL of MDP (MDP-low) up-regulated TNF-α by 29%, while 100

Synthesis and Biological Activity of 6-O-(3-Acyloxytetradecanoyl)-N-acetyl-muramoyl Dipeptide Methyl Esters and Related Compounds

A variety of 6-O-(3-acyloxytetradecanoyl)-MDP methyl esters were synthesized using optically-active (3R)-3-acyloxytetradecanoic acid.Their immunoadjuvant activity was examined.

Synthesis of β(1-4)-Linked Disaccharides of N-Acetylglucosamine and3 N-Acetylmuramic Acid by Their Direct Condensation

As a basic study in the synthetic approach to immunoactive cell wall peptid3oglycan whose backbone is a β(1-4)-linked saccharide of alternating glucosamine and3 muramic acid, methods for the direct condensation of these sugar components were studied and O-(N-acetyl-β-muramyl)-(1->4)-N-acetyl-D-glucosamine and O-(N-acetyl-β-D-glucosaminyl)-(1->4)-N-acetylmuramic acid were synthesized.In the synthesis of the latter disaccharide, previous formation of an ester bond between the carboxyl group of muramic acid and the 6-hydroxyl group of glucosamine proved to facilitate the glycoside bond formation between these sugar moieties.

Synthesis of carbohydrate analogs (positional, configurational, and optical) of n-acetylmuramoyl-L-alanyl-D-isoglutamine, and their immunoadjuvant activities.

2-Acetamido-2-deoxy-4- and -6-O-(D-2-propanoyl-L-alanyl-D-isoglutamine)-D-glucopyranose, 2-acetamido-2-deoxy-3-O-(D-2-propanoyl-L-alanyl-D-isoglutamine)-D-allopyranose, -D-gulopyranose, -D-galactopyranose, -D-mannopyranose, and -L-idopyranose, and 3-O-(D-2-propanoyl-L-alanyl-D-isoglutamine)-D- and -L-glucopyranose were synthesized, in order to clarify the structural requirements for the immunoadjuvant activity of the carbohydrate moiety in N-acetylmuramoyl-L-alanyl-D-isoglutamine. Immunoadjuvant activity of the N-acetylmuramoyl-dipeptide analogs was examined in guinea-pigs.