693232-15-4Relevant articles and documents
Nickel-Catalyzed α-Carbonylalkylarylation of Vinylarenes: Expedient Access to γ,γ-Diarylcarbonyl and Aryltetralone Derivatives
Dhungana, Roshan K.,Giri, Ramesh,Khanal, Namrata,Shekhar, K. C.
supporting information, p. 8047 - 8051 (2020/04/30)
We report a Ni-catalyzed regioselective α-carbonylalkylarylation of vinylarenes with α-halocarbonyl compounds and arylzinc reagents. The reaction works with primary, secondary, and tertiary α-halocarbonyl molecules, and electronically varied arylzinc reagents. The reaction generates γ,γ-diarylcarbonyl derivatives with α-secondary, tertiary, and quaternary carbon centers. The products can be readily converted to aryltetralones, including a precursor to Zoloft, an antidepressant drug.
2-(Biarylalkyl)amino-3-(cyanoalkanoylamino)pyridine derivatives
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Page/Page column 17, (2010/02/05)
Compounds disclosed herein are bradykinin B1 antagonist compounds useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.
