693258-54-7Relevant academic research and scientific papers
Hiyama reactions of activated and unactivated secondary alkyl halides catalyzed by a nickel/norephedrine complex
Strotman, Neil A.,Sommer, Stefan,Fu, Gregory C.
, p. 3556 - 3558 (2008/02/14)
(Chemical Equation Presented) An active partner: Nickel in combination with an amino alcohol ligand (norephedrine) was found to provide the most versatile and efficient catalyst for Hiyama cross-coupling reactions of alkyl electrophiles that has been described to date. Unprecedented Hiyama reactions of activated secondary alkyl bromides were achieved, as were the first Hiyama couplings of (activated) alkyl chlorides (see scheme, X = Br, Cl; HMDS = 1,1,1,3,3,3-hexamethyldisilazane, DMA = N,N-dimethylacetamide).
Stille cross-couplings of unactivated secondary alkyl halides using monoorganotin reagents
Powell, David A.,Maki, Toshihide,Fu, Gregory C.
, p. 510 - 511 (2007/10/03)
The first catalyst that achieves Stille cross-couplings of secondary (as well as primary) alkyl halides has been developed. The method employs easily handled and inexpensive catalyst components (NiCl2 and 2,2′-bipyridine) and, through the use of monoorganotin reagents, avoids the formation of toxic and difficult-to-remove triorganotin side products. Copyright
