693261-99-3

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 693262-03-2 N-benzyl-N-methyl-N-[3-hydroxy-3-(4-methoxyphenyl)]propylamine 

Downstream Products

• 693262-32-7 (+/-) ethyl 3-[N-methyl-N-(3-hydroxy-3-(4-methoxyphenyl)-propyl)]-aminopropionate 
• 693262-31-6 methyl (+/-)-3-[N-methyl-N-(3-hydroxy-3-(4-methoxyphenyl)-propyl)]aminopropionate 

Relevant academic research and scientific papers

Practical synthesis of enantiopure γ-amino alcohols by rhodium-catalyzed asymmetric hydrogenation of β-secondary-amino ketones

(Chemical Equation Presented) Another way to antidepressants: A series of β-secondary-amino ketone hydrochlorides (e.g. 1) were hydrogenated with remarkably high enantioselectivities by using a Rh complex containing P-chiral bisphospholane 2. These results establish a short and practical means for the synthesis of enantiopure N-monosubstituted γ-amino alcohols (e.g. 3), which are key intermediates in the synthesis of important antidepressants. (nbd = norbornadiene; TON = turnover number).

NOVEL PROCESS FOR THE PREPARATION OF 4-ARYL-3-HYDROXYMETHYL-1-METHYLPIPERIDINES.

A novel, improved, and general process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines is disclosed in the present invention. 4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine is a well-known intermediate in making the anti-depressan