693285-69-7

Usage

Uses

Used in Medicinal Chemistry:
[3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID is used as a building block for the synthesis of biologically active molecules, contributing to the development of new pharmaceuticals. Its unique structure and functional group enable the creation of diverse compounds with potential therapeutic applications.
Used in Drug Discovery:
In the realm of drug discovery, [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID serves as a valuable tool for identifying and optimizing potential drug candidates. Its interaction with diols and other Lewis bases can be exploited to design molecules with specific biological activities, aiding in the discovery of novel therapeutic agents.
Used in Chemical Biology Research:
[3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID is also utilized as a research tool in chemical biology. Its ability to form stable complexes with various biomolecules allows for the investigation of their structure, function, and interactions, furthering our understanding of biological processes and the development of targeted therapies.
Used in Chemical Reactions:
As a boronic acid derivative, [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID is employed in various chemical reactions, particularly those involving the formation of stable complexes with diols and other Lewis bases. This property makes it a useful agent in the synthesis of complex organic molecules and the development of new chemical methodologies.
Used in Sensor Development:
[3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID's capacity to form stable complexes with diols and other Lewis bases also makes it a potential candidate for the development of sensors targeting specific biomolecules. This application could have significant implications in the fields of diagnostics, environmental monitoring, and bioanalytical chemistry.

Downstream Products

• 693278-06-7 4-[4-isopropoxy-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyridin-2-yl]-3-isopropyl-1H-indazole 

Relevant academic research and scientific papers

3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES

The present invention provides compounds of Formula (I) or (II) salt form or prodrug thereof, wherein variables are defined herein, that are modulators of metalloproteases such as matrix metalloproteases (MMPs) and ADAMs. The compounds or compositions described herein can be used to treat diseases associated with metalloprotease activity including, for example, arthritis, cancer, cardiovascular disorders, skin disorders, inflammation or allergic conditions.

4,5-DISUBSTITUTED-2-ARYL PYRIMIDINES

4,5-disubstituted-2-arylpyrimidines of Formula (I) and Formula (II) are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I and II bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 4,5-disubstituted-2-arylpyrimidines, which are useful as probes for the localization of C5a receptors.

1-ARYL-4-SUBSTITUTED ISOQUINOLINES

1-Aryl-4-substituted isoquinolines analogues of Formula (I) and Formula (II) are provided, as follows : wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) and (II) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 1-aryl-4-substituted isoquinolines, which are useful as probes for the localization of C5a receptors.

3-SUBSTITUTED-6-ARYL PYRIDINES

3-substituted-6-aryl pyridines of Formula (I) are provided: Formula (I) wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 3-substituted-6-aryl pyridines, which are useful as probes for the localization of C5a receptors.