693285-69-7

Basic information

• Product Name: [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID
• Synonyms: [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID;Boronic acid, [3-(1-Methylethyl)-1H-indazol-4-yl]-
• CAS NO: 693285-69-7
• Molecular Formula: C₁₀H₁₃BN₂O₂
• Molecular Weight: 0
• Mol File: 693285-69-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID(693285-69-7)
• EPA Substance Registry System: [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID(693285-69-7)

Safety Data

• Hazardous Substances Data: 693285-69-7(Hazardous Substances Data)

Usage

General Description

[3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID is an organic compound with the chemical formula C11H13BN2O2. It is a boronic acid derivative with a 1H-indazole core structure and a boronic acid functional group. [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID has potential applications in medicinal chemistry and drug discovery due to its ability to act as a building block for the synthesis of biologically active molecules. Boronic acids are known for their ability to form stable complexes with diols and other Lewis bases, making them useful in various chemical reactions and as sensors for biomolecules. The [3-(1-METHYLETHYL)-1H-INDAZOL-4-YL] BORONIC ACID may have potential uses in the development of new pharmaceuticals or as a tool in chemical biology research.

Downstream Products

• 693278-06-7 4-[4-isopropoxy-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyridin-2-yl]-3-isopropyl-1H-indazole 

Relevant articles and documents

3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES

The present invention provides compounds of Formula (I) or (II) salt form or prodrug thereof, wherein variables are defined herein, that are modulators of metalloproteases such as matrix metalloproteases (MMPs) and ADAMs. The compounds or compositions described herein can be used to treat diseases associated with metalloprotease activity including, for example, arthritis, cancer, cardiovascular disorders, skin disorders, inflammation or allergic conditions.

1-ARYL-4-SUBSTITUTED ISOQUINOLINES

1-Aryl-4-substituted isoquinolines analogues of Formula (I) and Formula (II) are provided, as follows : wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula (I) and (II) bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 1-aryl-4-substituted isoquinolines, which are useful as probes for the localization of C5a receptors.