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N-4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl-2-hydroxybenzamide, also known as CPPHA, is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5). It selectively potentiates the activation of human and rat mGluR5 by glutamate, 3,5-DHPG, and quisqualate, with EC50s ranging from 0.316-0.5 and 0.634-1.16 μM, respectively. Although it is selective for mGluR5, it also exhibits submicromolar activity at PDE6, δand κ-opioid receptors, and the ether-a-go-go related gene (ERG) potassium channel.

693288-97-0

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693288-97-0 Usage

Uses

Used in Pharmaceutical Industry:
CPPHA is used as a therapeutic agent for the treatment of neurological disorders, such as Parkinson's disease and schizophrenia. It modulates the activity of mGluR5, which plays a crucial role in the regulation of synaptic transmission and plasticity in the central nervous system. By potentiating mGluR5 activation, CPPHA can enhance the therapeutic effects of conventional treatments and improve the overall management of these disorders.
Used in Research Applications:
CPPHA is used as a research tool for studying the role of mGluR5 in various physiological and pathological processes. It helps researchers to understand the molecular mechanisms underlying the regulation of synaptic transmission and plasticity, as well as the involvement of mGluR5 in the pathophysiology of neurological disorders. This knowledge can contribute to the development of novel therapeutic strategies targeting mGluR5 for the treatment of various diseases.
Used in Drug Discovery and Development:
CPPHA is used as a lead compound in the discovery and development of new drugs targeting mGluR5. Its selective and potent activity at mGluR5 makes it a valuable starting point for the design and optimization of novel mGluR5 modulators with improved pharmacological properties and therapeutic potential. These new compounds can be further evaluated for their efficacy and safety in preclinical and clinical studies, ultimately leading to the development of innovative treatments for neurological disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 693288-97-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,9,3,2,8 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 693288-97:
(8*6)+(7*9)+(6*3)+(5*2)+(4*8)+(3*8)+(2*9)+(1*7)=220
220 % 10 = 0
So 693288-97-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H15ClN2O4/c23-14-9-10-18(24-20(27)17-7-3-4-8-19(17)26)13(11-14)12-25-21(28)15-5-1-2-6-16(15)22(25)29/h1-11,26H,12H2,(H,24,27)

693288-97-0 Well-known Company Product Price

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  • Sigma

  • (C2247)  CPPHA  ≥98% (HPLC)

  • 693288-97-0

  • C2247-5MG

  • 4,669.47CNY

  • Detail
  • Sigma

  • (C2247)  CPPHA  ≥98% (HPLC)

  • 693288-97-0

  • C2247-25MG

  • 18,579.60CNY

  • Detail

693288-97-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide

1.2 Other means of identification

Product number -
Other names CPPHA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:693288-97-0 SDS

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