69334-75-4Relevant academic research and scientific papers
3-Methyleneazetidine derivatives
-
, (2008/06/13)
This invention provides a novel class of 3-methyleneazetidines which include diphenylmethyl derivatives such as 1-isopropyl-3-diphenylmethyleneazetidine oxalate: STR1 This illustrated 3-methyleneazetidine compound is characterized by a combination of phar
Production of methylene-cycloamines
-
, (2008/06/13)
This invention provides an improved process for producing methylene-cycloamines as exemplified by 1-isopropyl-3-diphenylmethyleneacetidine: STR1 In accordance with the invention process, the above illustrated methyleneazetidine compound is synthesized by (1) reacting α,α-diphenyl-α-(1-isopropyl-3-azetidinyl) acetamide with bromine and alkali metal alkoxide under modified Hofmann Rearrangement conditions to form a carbamate intermediate, and (2) heating the carbamate intermediate in an acidic medium to yield the 1-isopropyl-3-diphenylmethyleneazetidine product. This illustrated 3-methyleneazetidine compound is characterized by a combination of pharmacological properties which are indicative of utility as a mood elevating therapeutic agent for relieving the symptoms of depression in humans.
Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods
-
, (2008/06/13)
α-(1-R-3-Azetidinyl)-α-phenyl-α-substituted-acetamides and -acetonitriles represented by the following formula: STR1 wherein R represents hydrogen, lower alkyl, lower cycloalkyl or phenyllower alkyl, R1 represents phenyl or 2-pyridyl, and Y is
