69343-99-3

Usage

Uses

Used in Scientific Research:
5-Bromo-1H-indol-3-amine is used as a chemical intermediate for the synthesis of more complex compounds in the field of chemistry and biochemistry. Its role as a building block allows researchers to create a variety of molecules with potential applications in different areas of science.
Used in Chemical Synthesis:
In the chemical industry, 5-Bromo-1H-indol-3-amine is used as a starting material for the synthesis of various organic compounds. Its unique structure, which includes a bromine atom, makes it a valuable component in the creation of new molecules with specific properties and potential uses.
Used in Biochemical Studies:
5-Bromo-1H-indol-3-amine is also utilized in biochemical research to understand the interactions and reactions of indole amines with other biomolecules. This can lead to insights into the biological roles of these compounds and their potential applications in medicine or other fields.
Used in Controlled Environments:
Due to the uncertainty surrounding its safety and toxicity, 5-Bromo-1H-indol-3-amine is used in controlled environments, such as laboratories, where proper handling and storage protocols can be implemented to minimize risks associated with its use. This ensures that researchers can work with the compound safely and effectively.

InChI:InChI=1/C8H7BrN2/c9-5-1-2-8-6(3-5)7(10)4-11-8/h1-4,11H,10H2

Upstream product

• 76983-63-6 5-Bromo-3-nitroso-1H-indole 
• 1260655-97-7 5-bromo-3-nitro-1H-indole 
• 10406-06-1 5-bromo-1H-indole-3-carboxylic acid 
• 10075-50-0 5-bromo-1H-indole 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or prodrug, and/or tautomer, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same. Formula (I).

Synthesis of 3-Aminoindoles & Ethyl Pyrroloindole-2-carboxylates

Various indoles (1a-g) on nitrosation with sodium nitrite and acetic acid yield the corresponding 3-nitrosoindoles (2a-g).These on reduction with sodium dithionate, in the presence of 2 N NaOH, afford 3-aminoindoles (3a-g) in good yields.Coupling of a diazotised solution of 3a-g with ethyl α-methylacetoacetate (5) yields the respective ethyl indol-3-ylpyruvate hydrazones (6a-g) which on Fischer indolization with alcoholic H2SO4 give various ethyl pyrroloindole-2-carboxylates (7a-g).