6937-78-6Relevant academic research and scientific papers
Improved synthesis dimethylhomoecoerdianthrone (HOCD) and its functionalization through facile amination reactions
Wu, Haixia,Chen, Wei,Yang, Hui,Wang, Suhua,Lim, Si Ting,Yao, Wei,Guo, Juanjuan,Li, Tianhu,Wong, Ming Wah,Huang, Dejian
, p. 154 - 161 (2016)
An improved synthesis of dimethylhomoecoerdianthrone (HOCD), a dye used for singlet oxygen detection, was reported by isolation of a key intermediate followed by cyclization reaction. Moreover, dehydrogenative amination reaction between HOCD and alkyl ami
Dye and fluorescent probe for detecting singlet oxygen and manufacturing method of dye and fluorescent probe
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Paragraph 0043; 0052; 0058, (2017/09/08)
The application discloses a synthetic method of a dye compound used for sensitive detection of singlet oxygen. Furthermore, a fluorescent probe having a part of different fluorescent groups of the dye compound is designed and is synthesized through a new
Synthesis of new polycyclic anthracenedione analogs with hetero- Or carbocyclic ring(s) fused to the chromophore system
Dzieduszycka,Stefanska,Gawronska,Arciemiuk,Borowski
, p. 535 - 545 (2008/09/17)
A series of novel anthracenedione analogs with various hetero- or carbocyclic ring(s) incorporated into the chromophore has been synthesized. These compounds may constitute a new class of anthracenedione agents with potential ability to overcome multidrug resistance of cancer cells.
1,4-disubstituted anthracene antitumor agents
Iyengar, Bhashyam S.,Dorr, Robert T.,Alberts, David S.,Sólyom, Anikó M.,Krutzsch, Mary,Remers, William A.
, p. 3734 - 3738 (2007/10/03)
Three different types of 1,4-disubstituted anthracenes were synthesized, and their cytotoxicity in a panel of tumor cells was compared with that of the corresponding 9,10-disubstituted anthracenes. The panel contained human myeloma, melanoma, colon, and lung cancer cells and sensitive and multidrug- resistant murine L1210 leukemia cells. These compounds had [[(dimethylamino)ethyl]amino]methyl, N-[(dimethylamino)ethyl]carbamoyl, and carboxaldehyde (4,5-dihydro-1H-imidazol-2-yl)hydrazone side chains. The 1,4- diamide was more potent across the tumor panel than the corresponding 9,10- isomer, but the 1,4-diamine and the 1,4-hydrazone were less potent than their 9,10-isomers. Although the 1,4-hydrazone was active against P388 leukemia in mice, it was inactive against L1210 leukemia. Within each pair of compounds, the one with greater average potency against tumor cells gave a greater increase in the transition melt temperature of DNA.
