69370-84-9

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 118-00-3 G 
• 2096-10-8 adenosine-2-amine 
• 115913-81-0 N²-acetyl-2'-O-tosyl-2,6-diamino-9-β-D-ribofuranosylpurine 
• 121231-93-4 2,6-diamino-9-(<2'-O-(p-tosyl)sulfonyl>-β-D-ribofuranosyl)purine 

Downstream Products

• 92562-88-4 9-(2,3-dideoxy-3-fluoro-β-D-erythro-pentofuranosyl)guanine 
• 115913-82-1 5'-O-benzoyl-3'-fluoro-2',3'-dideoxyguanosine 
• 115913-75-2 9-(5-O-benzoyl-2-deoxy-β-D-threo-pentofuranosyl)guanine 
• 115913-77-4 5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine 
• 115913-76-3 N²-<(dimethylamino)methylene>-5'-O-benzoyl-3'-azido-2',3'-dideoxyguanosine 

Relevant academic research and scientific papers

Study on disulfur-backboned nucleic acids: Part IV. Efficient synthesis of 3′,5′-dithio-2′-deoxyguanosine

An efficient and novel method for synthesizing 3′,5′-dithio-2′-deoxyguanosine was described. In this method normal guanosine was used as the starting material. A very efficient procedure was used to synthesize 2?-O-tosylguanosine 1, which used 0.1 eq. DBT

Deoxygenative [1,2]-hydride shift rearrangements in nucleoside and sugar chemistry: Analogy with the [1,2]-electron shift in the deoxygenation of ribonucleotides by ribonucleotide reductases

(Chemical Equation Presented) A variant of the semipinacol rearrangement that was observed in our laboratory has been applied to the synthesis of several furanose and pyranose derivatives. The process consists of an "orchestrated" [1,2]-hydride shift with

Deacetylation of 2′-O-Ts-3′,5′-di-O-acetylpurine nucleosides via a free radical reaction

A new method for deprotecting acetyl groups of blocked purine nucleosides has been established by using tri-n-butyltin hydride (n-Bu3SnH) in the presence of α, α′-azobisisobutyronitrile (AIBN) without affecting OTs group.

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

A series of base-modified pyrimidine 3'-azido-2',3'-dideoxynucleosides and 3'-substituted purine and pyrimidine 2',3'-dideoxynucleosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. The following pyrimidine derivatives emerged as the most potent and/or selective inhibitors of HIV-induced cytopathogenicity (in order of decreasing selectivity: 3'-azido-3'-deoxythymidine (AZT), 3'-azido-2',3'-dideoxyuridine (AzddUrd), 3'-azido-2',3'-dideoxy-5-methylcytidine (AzddMeCyd), 3'-fluoro-ddUrd (FddUrd), 3'-fluoro-ddThd (FddThd), the N4-hydroxylated derivative of AzddMeCyd and the N4-methylated derivative of AzddMeCyd. Among the purine 2',3'-dideoxynucleosides, 3'-azido-2',3'-dideoxyguanosine (AzddGuo), 3'-fluoro-ddGuo (FddGuo), and 3'-fluoro-2,6-diaminopurine 2',3'-dideoxynucleoside (FddDAPR) were the most selective inhibitors of HIV replication.