69370-99-6Relevant academic research and scientific papers
Rigid Scaffolds: Synthesis of 2,6-Bridged Piperazines with Functional Groups in all three Bridges
Gao, Donglin,Penno, Christian,Wünsch, Bernhard
, p. 874 - 889 (2020/09/02)
The activity of pharmacologically active compounds can be increased by presenting a drug in a defined conformation, which fits exactly into the binding pocket of its target. Herein, the piperazine scaffold was conformationally restricted by substituted C
