693790-26-0Relevant articles and documents
Total synthesis of (-)-pateamine A, a novel immunosuppressive agent from Mycale sp
Pattenden, Gerald,Critcher, Douglas J.,Remuinan, Modesto
, p. 353 - 365 (2004)
A convergent synthesis of the unique thiazole-containing polyene bis-lactone pateamine A (1) isolated from the marine sponge Mycale sp is described. The synthesis features the ubiquitous Stille sp2-sp 2 coupling reaction to elaborate the E,Z-diene macrolide core 23 and the all-E polyenamine side chain in the natural product. It also highlights the scope for enantiopure sulfinimine intermediates in the synthesis of chiral β-amino ester moieties in complex structures.