69383-92-2Relevant academic research and scientific papers
INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 134; 135, (2010/11/24)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I); wherein Y, L, Z, W, X, Q, R1, R2 and R3 are as defined in the specification.
New amino acid porphyrin derivatives. Part I: Synthesis
Perree-Fauvet, Martine,Verchere-Beaur, Catherine,Tarnaud, Eric,Anneheim-Herbelin, Gilles,Bone, Nathalie,Gaudemer, Alain
, p. 13569 - 13588 (2007/10/03)
In order to obtain molecules that can bind to specific DNA-sequences, several new tri-(N-methyl-4-pyridiniumyl)porphyrins bearing an amino acid or peptide side-chain on the fourth meso aromatic substituent have been synthesized by efficient coupling of a
PHENOXYPROPYL DERIVATIVES
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, (2008/06/13)
A phenoxypropyl derivative represented by the following formula STR1 wherein A represents a formyl group, a protected formyl group, a hydroxymethyl group, a protected hydroxymethyl group, or a halomethyl group, and Z represents a halogen atom, an amino gr
PHARMACOLOGICALLY ACTIVE AMINOALKYLPHENYL COMPOUNDS AND THEIR USE
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, (2008/06/13)
Compounds of the general formula: STR1 and physiologically acceptable salts, and hydrates, N-oxides and bioprecursors of such compounds and such salts in whichR 1 and R 2, which may be the same or different, represent hydrogen or lower alkyl, cycloalkyl, aralkyl or lower alkenyl groups, or lower alkyl groups interrupted by an oxygen atom or a group STR2 in which R 4 represents hydrogen or lower alkyl; or R 1 and R 2 may, together with the nitrogen atom to which they are attached form a heterocyclic ring which may contain the hetero functions--O--and STR3 R 3 represents hydrogen, lower alkyl, alkenyl or alkoxyalkyl; X represents--O--,--S--or--CH 2--or STR4 where R 5 is hydrogen or lower alkyl; Y represents =S, =O, =NR 6 or =CHR. sub.7 ;in which R 6 represents hydrogen, nitro, cyano, lower alkyl, aryl, arylsulphonyl or lower alkylsulphonyl; R 7 represents nitro, lower alkylsulphonyl or arylsulphonyl; m is an integer from 2 to 4 inclusive; n is zero, 1 or 2; and Alk denotes a straight or branched alkylene chain of 1 to 6 carbon atoms. The compounds have therapeutic activity.
CHEMICAL INTERMEDIATES AND PROCESS
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, (2008/06/13)
The present invention relates to novel intermediates of the formula STR1 wherein R 1 is hydrogen or lower alkyl and R is STR2--CH 2 OH or--CH 2 X in which X is a conventional leaving group and Y is lower alkyl and the use thereof in a process for the prep
