69385-97-3Relevant academic research and scientific papers
Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists
Berlin, Michael,Lee, Yoon Joo,Boyce, Christopher W.,Wang, Yi,Aslanian, Robert,McCormick, Kevin D.,Sorota, Steve,Williams, Shirley M.,West Jr., Robert E.,Korfmacher, Walter
, p. 2359 - 2364 (2010)
Structural features of the substituted 4-piperidinyl urea analogs 1, responsible for the H3 antagonist activity, have been identified. Structure-activity relationship of the H3 receptor affinity, hERG ion channel inhibitory activity and their separation is described. Preliminary pharmacokinetic evaluation of the compounds of the series is addressed.
