69388-90-5

Upstream product

• 69388-89-2 penicillanic acid 4-nitro-benzyl ester 
• 76350-35-1 potassium penicillanate 1,1-dioxide 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 68373-14-8 sulbactum 
• 81752-49-0 p-nitrobenzyl 3-methyl-2<(2R)-2-methylsulphonyl-4-oxoazetidin-1-yl>but-2-enoate 
• 88209-25-0 p-nitrobenzyl<3-2H>penicillanate 1,1-dioxide 

Relevant academic research and scientific papers

Studies Related to Penicillins. Part 21. β-Elimination Reactions of S,S-Dioxides of Penicillanic Esters

In the presence of 1,5-diazabicyclonon-5-ene (DBN), methyl benzylpenicillinate 1,1-dioxide (3a) is converted into (2S,3R)-1-(1-methoxycarbonyl-2-methylprop-1-enyl)-4-oxo-3-phenylacetamidoazetidine-2-sulphinic acid (5a).Corresponding reactions are o

Penicillanic acid 1,1-dioxides as β-lactamase inhibitors

Penicillanic acid 1,1-dioxide, and esters thereof readily hydrolyzable in vivo, are useful as antibacterial agents, and also for enhancing the effectiveness of several β-lactam antibiotics against many β-lactamase producing bacteria. Derivatives of penicillanic acid 1,1-dioxide having the carboxy group protected by a conventional penicillin carboxy protecting group are useful intermediates to penicillanic acid 1,1-dioxide. Penicillanic acid 1-oxides and certain esters thereof are useful chemical intermediates to penicillanic acid 1,1-dioxide and its esters.