69394-31-6

Upstream product

• 57794-27-1 rel-(1S,2S,4R,5R)-2,4-Diphenyl-3-azabicyclo<3.3.1>nonan-9-on 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 

Downstream Products

• 64259-31-0 anti-2,4-Diphenyl-3-methyl-9-ethynyl-3-azabicyclo<3.3.1>nonan-9-ol 
• 1203965-33-6 C₂₈H₃₀N₂O 
• 99422-88-5 anti-2,4-Diphenyl-3-methyl-9-ethynyl-3-azabicyclo<3.3.1>nonan-9-yl acetate 
• 91658-74-1 1,4-Bis(2,4-diphenyl-9-hydroxy-3-methyl-3-azabicyclo<3.3.1>nonan-9-yl)diacetylene 

Relevant academic research and scientific papers

Synthesis, stereochemistry and antimicrobial studies of novel oxime ethers of aza/diazabicycles

Two series of bicyclic oxime ethers viz, 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one O-benzyloximes 13-24 and 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-one O-benzyloximes 31-36 were synthesized and stereochemistry was established by their spectral (1D and 2D NMR) and crystal studies. Synthesized oxime ethers were screened for their in vitro antimicrobial activity against a set of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans, Candida-51, Rhizopus sp., Aspergillus niger and Aspergillus flavus) by twofold serial dilution method, respectively, using Ciprofloxacin and Amphotericin B as standards. Most of the molecules expressed promising antimicrobial profile against the tested pathogens and even a few compounds 16, 21, 22, 33 and 34 were better than standard drugs.