694-24-6

Basic information

• Product Name: 2,3-dihydro-1-hydroxy-1H-phosphole 1-oxide
• Synonyms: 2,3-dihydro-1-hydroxy-1H-phosphole 1-oxide
• CAS NO: 694-24-6
• Molecular Formula: C₄H₇O₂P
• Molecular Weight: 118.070941
• EINECS: 211-768-3
• Mol File: 694-24-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 392°C at 760 mmHg
• Flash Point: 190.9°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 3.09E-07mmHg at 25°C
• Refractive Index: 1.487
• CAS DataBase Reference: 2,3-dihydro-1-hydroxy-1H-phosphole 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dihydro-1-hydroxy-1H-phosphole 1-oxide(694-24-6)
• EPA Substance Registry System: 2,3-dihydro-1-hydroxy-1H-phosphole 1-oxide(694-24-6)

Safety Data

• Hazardous Substances Data: 694-24-6(Hazardous Substances Data)

Usage

Type of compound

phosphole oxide (a type of organophosphorus compound)

Physical state

colorless liquid

Solubility

soluble in polar solvents such as water

Uses

reagent in organic synthesis (particularly in reactions involving phosphorus-containing compounds), potential use in pharmaceuticals, ligand in coordination chemistry

Properties

ability to interact with metal ions, catalyze certain reactions.

InChI:InChI=1/C4H7O2P/c5-7(6)3-1-2-4-7/h1,3H,2,4H2,(H,5,6)

Upstream product

• 69220-51-5 1,1,1-trichloro-3-phospholene 

Downstream Products

• 7549-49-7 3-(4-chloro-phenylsulfanyl)-1-oxo-1λ⁵-phospholan-1-ol 
• 76232-62-7 1-hydroxy-3-phenylphospholane 1-oxide 

Relevant articles and documents

Method for producing aluminum salts of cyclic phosphinic acids

A process for the preparation of aluminum salts of cyclic phosphinic acids is described, which comprises reacting cyclic phosphinic acids, such as 1-hydroxydihydrophosphole oxides or 1-hydroxyphospholane oxides, with aluminum hydroxide in the presence of water and in the absence of polar solvents at elevated temperature for a reaction time of from 1 to 20 hours.

A NEW REAGENT FOR THE MEDIATION OF AMIDE BOND FORMATION IN PEPTIDE SYNTHESIS.

The potential application of 1-oxo-1-chlorophospholane (5) as a novel reagent for the in situ activation of N α-protected amino acids for use in peptide bond forming reactions has been examined.Wherever possible, 32.4 MHz 31P nuclear magnetic resonance (n.m.r.) spectroscopy was employed to follow both the formation of the intermediate phospholanic-carboxylic mixed anhydride and the subsequent aminolysis reaction.