L-PHENYLALANINE DEHYDROGENASE, also known as a NAD+-dependent oxidoreductase, is an enzyme that catalyzes the reversible, oxidative deamination of L-phenylalanine, leading to its degradation. It plays a crucial role in the metabolism of phenylalanine and the biosynthesis of phenylalanine, tyrosine, and tryptophan.
69403-12-9
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Basic information
- Product Name: L-PHENYLALANINE DEHYDROGENASE
- Synonyms: L-PHEDH;L-PHENYLALANINE:NDA+-OXIDOREDUCTASE;L-PHENYLALANINE DEHYDROGENASE;L-PHENYLALANINE DEHYDROGENASE, RHODOCOCCUS SPECIES M4;L-PHENYLALANINE:NAD+-OXIDOREDUCTASE;L-PHENYLALANINE: NAD+ OXIDOREDUCTASE [DEAMINATING];EC 1.4.1.20;EC 1.4.1
- CAS NO:69403-12-9
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: Oxidoreductases;Specialty Enzymes;1.4.x.x Acting on CH-NH2;1.x.x.x Oxidoreductases;General Metabolic Enzymes;General Metabolic Enzymes I-ZEnzyme Class Index;Metabolomics
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: light yellow/solution (clear)
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: L-PHENYLALANINE DEHYDROGENASE(CAS DataBase Reference)
- NIST Chemistry Reference: L-PHENYLALANINE DEHYDROGENASE(69403-12-9)
- EPA Substance Registry System: L-PHENYLALANINE DEHYDROGENASE(69403-12-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 69403-12-9(Hazardous Substances Data)
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69403-12-9 Usage
Uses
Used in Research and Development:L-PHENYLALANINE DEHYDROGENASE is used as a research tool for studying [application type] phenylalanine metabolism and [application reason] the biosynthesis of phenylalanine, tyrosine, and tryptophan. This enzyme helps researchers understand the metabolic pathways and regulatory mechanisms involved in these processes.
Used in Pharmaceutical Industry:
L-PHENYLALANINE DEHYDROGENASE is used as a therapeutic target for [application type] the development of treatments for phenylketonuria (PKU) and other related metabolic disorders [application reason] caused by the deficiency or dysfunction of this enzyme. By targeting this enzyme, pharmaceutical companies can develop drugs that can potentially improve the symptoms and management of these conditions.
Used in Diagnostics:
L-PHENYLALANINE DEHYDROGENASE is used as a diagnostic marker for [application type] detecting and monitoring the levels of phenylalanine in the body [application reason] to assess the effectiveness of treatments for PKU and other related metabolic disorders. This enzyme can also be used to identify individuals with genetic predispositions to these conditions, allowing for early intervention and management.
Used in Food Industry:
L-PHENYLALANINE DEHYDROGENASE is used as a processing aid for [application type] the production of phenylalanine-free or low-phenylalanine foods [application reason] for individuals with PKU and other related metabolic disorders. By utilizing this enzyme, the food industry can cater to the specific dietary needs of these individuals, ensuring a safer and more inclusive range of food products.
Biochem/physiol Actions
Phenylalanine dehydrogenase (PheDH) is considered as an effective enzyme to estimate the quantity of phenylalanine to distinguish phenylketonuria (PKU) disease.Check Digit Verification of cas no
The CAS Registry Mumber 69403-12-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,4,0 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.Calculate Digit Verification of CAS Registry Number 69403-12:
(7*6)+(6*9)+(5*4)+(4*0)+(3*3)+(2*1)+(1*2)=129
129 % 10 = 9
So 69403-12-9 is a valid CAS Registry Number.
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L-PHENYLALANINE DEHYDROGENASE
