69405-03-4Relevant articles and documents
Synthesis and biological evaluation of new curcumin analogs inhibiting osteoclastogenesis
Kawano, Tomikazu,Matsumoto, Naomi,Nakanishi-Matsui, Mayumi,Ogawa, Satoshi,Ohashi, Toshika,Sugawara, Aoi,Tamura, Satoru
, p. 1233 - 1247 (2020/09/18)
A series of curcumin analogs (1-3) were newly designed and synthesized for the development of therapeutic agents for osteoporosis. Among the synthesized compounds, 2,5-substituted conjugated thiophene derivative (1a) and the corresponding pyrazine derivat
Synthesis of Two Natural Furan-Cyclized Diarylheptanoids via 2-Furaldehyde
Se?inti, Hatice,Se?en, Hasan
, p. 938 - 944 (2015/11/23)
Two natural diarylheptanoids, 2-benzyl-5-(2-phenylethyl)furan (1) and 2-methoxy-4-{[5-(2-phenylethyl)furan-2-yl]methyl}phenol (2), were synthesized starting from 2-furaldehyde. A Wittig reaction of 2-furaldehyde with benzyltriphenylphosphonium bromide followed by reduction of the alkene C=C bond with Mg gave 2-(2-phenylethyl)furan (5). Lithiation of 5 with BuLi at -78 followed by alkylation with benzyl bromide gave natural product 1. In another approach, Friedel-Crafts acylation of compound 5 with benzoyl chloride followed by deoxygenation of the C=O group afforded 1. The natural product 2 was also synthesized by acylation of 5 with 4-acetoxy-3-methoxybenzoyl chloride (16) followed by deoxygenation and deacetylation.
(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metbotropic glutamate mGluR1 receptors
Clark, Barry P.,Baker, S. Richard,Goldsworthy, John,Harris, John R.,Kingston, Ann E.
, p. 2777 - 2780 (2007/10/03)
The synthesis of three novel 4-carboxyphenylglycine (LY367385) selectively antagoises metabotropic glutamate mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer LY367385.
