6941-49-7

Basic information

• Product Name: 2-methylvaleramide
• Synonyms: 2-methylvaleramide
• CAS NO: 6941-49-7
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 0
• Mol File: 6941-49-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 245.2°C at 760 mmHg
• Flash Point: 102.1°C
• Appearance: /
• Density: 0.894g/cm³
• Vapor Pressure: 0.0291mmHg at 25°C
• Refractive Index: 1.431
• CAS DataBase Reference: 2-methylvaleramide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylvaleramide(6941-49-7)
• EPA Substance Registry System: 2-methylvaleramide(6941-49-7)

Safety Data

• Hazardous Substances Data: 6941-49-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H13NO/c1-3-4-5(2)6(7)8/h5H,3-4H2,1-2H3,(H2,7,8)

Upstream product

• 6339-13-5 2-methyl-Pentanenitrile 
• 116908-84-0 2-methylvaleryl chloride 
• 123-15-9 2-methylvaleraldehyde 
• 109-67-1 1-penten 
• 201230-82-2 carbon monoxide 
• 4371-03-3 methylpropylmalonic acid 
• 97-61-0 2-Methylpentanoic acid 
• 5870-68-8 ethyl 3-methylpentanoate 

Downstream Products

• 6339-13-5 2-methyl-Pentanenitrile 
• 13364-16-4 2-methylpentylamine 

Relevant articles and documents

Photoinduced remote regioselective radical alkynylation of unactivated C-H bonds

A method for the remote regioselective alkynylation of unactivated C(sp3)-H bonds in diverse aliphatic amides by photogenerated amidyl radicals has been developed. The site-selectivity is dominated via a 1,5-hydrogen atom transfer (HAT) process of the amide. Mild reaction conditions and high regioselectivity are demonstrated in this methodology.

Efficient heterogeneous hydroaminocarbonylation of olefins with ammonium chloride as amino source

An efficient protocol for heterogeneous hydroaminocarbonylation of olefins with ammonium chloride without addition of acid additive has been developed for the first time. We successfully synthesized the Pd@POPs-PPh3 catalyst through a solvothermal synthetic method. Under this heterogeneous catalytic system, C2-C6 olefins displayed good yields and TON, and a yield of 66% of propionamide and TON = 1400 were obtained under mild reaction conditions (403 K, Pethylene = 0.5 MPa, PCO = 2.5 MPa), which is a little higher than those in the homogeneous system. This catalytic system has the advantage of easy separation of product and catalyst, as well as good stability. Uniform dispersion of Pd active sites, strong coordination bond between P and Pd, high surface area, large pore volume and hierarchical porosity of Pd@POPs-PPh3 were confirmed by a series of characterizations, which is believed to be the keys for the good activity and stability of hydroaminocarbonylation reaction.

Facile One-pot conversion of aldehydes into amides

A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100°C and the subsequent treatment of the nitrile with basic hydrogen peroxide. The resulting amide products were produced in good yields (67-95%) and purity (>95%). Copyright