69411-06-9Relevant articles and documents
[jihidorokinorinon[jihidorokinorinon] compound
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Paragraph 0052; 0066, (2021/11/19)
5 - [To] {[ (4 - chloro - 2, 6 - difluorophenyl) - 3, 4 - dihydroxypiperidine (3R, 4R) -1 - -4 - yl] methoxy} - 3, 4 - dihydroquinoline - (1H) on production of the -8 - fluoro -2. [Solution] 5 - {[ (4 - chloro - 2, 6 - difluorophenyl) - 3, 4 - dihydroxypiperidine (3R, 4R) -1 - -4 - yl] methoxy} - 3, 4 - dihydroquinoline - (1H) on a crystal -8 - fluoro -2,(1) 5 - {[ (4 - Chloro - 2, 6 - difluorophenyl) - 3, 4 - dihydroxypiperidine (3R, 4R) -1 - -4 - yl] methoxy} - 3, 4 - dihydroquinoline - (1H) on an acceptable solvent -8 - fluoro -2 pharmaceutical manufacturing process flow, and (2) (1) cooling the resulting solution was stirred at the reflux process by providing a method comprising the steps of crystallization. [Drawing] no
TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS
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Page/Page column 47, (2012/09/10)
The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthama, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases. (I)
3-[Benz(ox/thi)azol-7-yl]-1h-pyrimidine-2,4-diones
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, (2008/06/13)
The invention relates to herbicidally effective 3-{benz(ox/thi)azol-7-yl}-1H-pyrimidine-2,4-diones of formula (I) wherein X=oxygen or sulphur, Y=oxygen or sulphur; Z=chemical bond, C1-C4-alkylene, O, S, SO, SO2; R1/s