69411-94-5

Usage

Type of compound

Organic chemical compound

Structure

Brominated benzene derivative with an allyloxy group and a bromomethyl group

Applications

Organic synthesis
Production of pharmaceuticals
Production of agrochemicals
Production of fine chemicals
Building block in the preparation of polymers
Building block in the preparation of specialty chemicals

Industry uses

Versatile compound with applications in various industries and research fields
These properties and specific content provide a comprehensive overview of 1-allyloxy-3-bromomethylbenzene, highlighting its molecular composition, structural features, and diverse applications across different industries.

Upstream product

• 34905-07-2 3-(2-propenyloxy)benzyl alcohol 
• 620-24-6 3-Hydroxybenzyl alcohol 

Downstream Products

• 644994-51-4 C₃₀H₃₀N₂O₃ 
• 931410-21-8 5-[3-(3-allyloxybenzyloxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile 
• 931409-85-7 5-[(3R)-3-(3-allyloxybenzyloxy)pyrrolidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile 

Relevant academic research and scientific papers

Novel Hypoxia-Inducible Factor 1α (HIF-1α) Inhibitors for Angiogenesis-Related Ocular Diseases: Discovery of a Novel Scaffold via Ring-Truncation Strategy

Ocular diseases featuring pathologic neovascularization are the leading cause of blindness, and anti-VEGF agents have been conventionally used to treat these diseases. Recently, regulating factors upstream of VEGF, such as HIF-1α, have emerged as a desirable therapeutic approach because the use of anti-VEGF agents is currently being reconsidered due to the VEGF action as a trophic factor. Here, we report a novel scaffold discovered through the complete structure-activity relationship of ring-truncated deguelin analogs in HIF-1α inhibition. Interestingly, analog 6i possessing a 2-fluorobenzene moiety instead of a dimethoxybenzene moiety exhibited excellent HIF-1α inhibitory activity, with an IC50 value of 100 nM. In particular, the further ring-truncated analog 34f, which showed enhanced HIF-1α inhibitory activity compared to analog 2 previously reported by us, inhibited in vitro angiogenesis and effectively suppressed hypoxia-mediated retinal neovascularization. Importantly, the heteroatom-substituted benzene ring as a key structural feature of analog 34f was identified as a novel scaffold for HIF-1α inhibitors that can be used in lieu of a chromene ring.

CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.