69412-06-2Relevant academic research and scientific papers
Process for the preparation substituted anilino acids
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, (2008/06/13)
Anilino acids of the formula STR1 wherein R is H or a metal cation; R2 is hydrogen or lower alkyl of 1 to 5 carbon atoms, lower alkenyl of 2 to 5 carbon atoms, lower haloalkyl of 1-4 carbon atoms, lower haloalkenyl of 2 to 4 carbon atoms, or lower cycloalkyl of 3 to 4 carbon atoms, Y is hydrogen, chloro, methyl group, or trifluoromethyl group, and X is hydrogen, chloro, or fluoro are prepared by reaction of an aryl halide of the formula STR2 where X1 is chloro or fluoro and X and Y are as defined above with the proviso that when X1 is chloro, X is hydrogen or chloro, and when X and Y are both chloro, X1 is fluoro with an α-amino acid of the formula STR3 where R and R2 are as defined above.
