6943-16-4Relevant academic research and scientific papers
Chiral Phosphoric Acid-Catalyzed Enantioselective Construction of 2,3-Disubstituted Indolines
Ma, Wei-Yang,Gelis, Coralie,Bouchet, Damien,Retailleau, Pascal,Moreau, Xavier,Neuville, Luc,Masson, Géraldine
supporting information, p. 442 - 448 (2021/01/26)
Highly enantio- and regioselective (3 + 2) formal cycloaddition of β-substituted ene- and thioenecarbamates as well as cyclic enamides with quinone diimides catalyzed by a BINOL- and SPINOL-derived phosphoric acid is reported. A wide variety of 2,3-disubstituted 2-aminoindolines, including polycyclic ones, were prepared in generally high yields (up to 98%) with moderate to complete diastereoselectivities and in most cases excellent enantioselectivities (up to 99% ee).
