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6943-23-3

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6943-23-3 Usage

General Description

2-(4-chlorophenyl)-6-methoxy-1H-benzimidazole is a chemical compound that belongs to the benzimidazole class of organic compounds. It is characterized by a benzene ring with a chloro group and a methoxy group attached to it. 2-(4-chlorophenyl)-6-methoxy-1H-benzimidazole is commonly used in pharmaceutical research and drug development due to its potential biological activities. It has been studied for its potential antimicrobial, antifungal, and anticancer properties. Additionally, 2-(4-chlorophenyl)-6-methoxy-1H-benzimidazole has been found to inhibit certain enzymes and has shown promise in treating various diseases and conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 6943-23-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,9,4 and 3 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6943-23:
(6*6)+(5*9)+(4*4)+(3*3)+(2*2)+(1*3)=113
113 % 10 = 3
So 6943-23-3 is a valid CAS Registry Number.

6943-23-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-chlorophenyl)-6-methoxy-1H-benzimidazole

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6943-23-3 SDS

6943-23-3Downstream Products

6943-23-3Relevant articles and documents

Transition-Metal-Free Transfer Hydrogenative Cascade Reaction of Nitroarenes with Amines/Alcohols: Redox-Economical Access to Benzimidazoles

Gujjarappa, Raghuram,Kabi, Arup K.,Malakar, Chandi C.,Musib, Dulal,Roy, Anupam,Sahoo, Abhishek,Singh, Virender,Vodnala, Nagaraju

, p. 14597 - 14607 (2021/11/12)

This report describes an efficient transition-metal-free process toward the transfer hydrogenative cascade reaction between nitroarenes and amines or alcohols. The developed redox-economical approach was realized using a combination of KOtBu and Et3SiH as reagents, which allows the synthesis of benzimidazole derivatives via σ-bond metathesis. The reaction conditions hold well over a wide range of substrates embedded with diverse functional groups to deliver the desired products in good to excellent yields. The mechanistic proposal has been depicted on the basis of a series of control experiments, mass spectroscopic evidence which is well supported by density functional theory (DFT) calculations with a feasible energy profile.

Graphene oxide-catalyzed CSp3–H activation of methylarenes in aqueous medium: A unified metal-free access to amides and benzimidazoles

Dandia, Anshu,Mahawar, Dinesh Kumar,Sharma, Ruchi,Badgoti, Ranveer Singh,Rathore, Kuldeep S.,Parewa, Vijay

, (2019/09/12)

Graphene oxide (GO)-catalyzed selective synthesis of amides via CSp3–H activation of methylarenes and consequent C–N bond formation with anilines under aqueous medium has been described. Oxygen functionality allied with GO surface played a dual role both as acid catalyst and oxidizing agent to some extent. However, GO has a copious effect on the reaction, shown by a high TOF value with TBHP as co-oxidant. The decisive role of carboxylic acid functional groups on GO nanosheets in this metal-free strategy has been confirmed and was monitored by various analytic techniques viz. Fourier transform-infrared, UV–Vis, Raman and XPS. A plausible mechanism was proposed by control experiments and by the isolation of the intermediate. Over-oxidation of methylarenes was not detected, and high recyclability of the carbocatalyst with its heterogeneous behavior facilitated the isolation and purification of the desired products. We have further explored the utility of this process for the chemoselective synthesis of benzimidazoles.

Efficient one-pot synthesis of 2-substituted benzimidazoles from triacyloxyborane intermediates

Cui, Wenge,Kargbo, Robert B.,Sajjadi-Hashemi, Zohreh,Ahmed, Feryan,Gauuan, Jolicia F.

experimental part, p. 247 - 250 (2012/02/15)

An efficient one-pot synthesis of 2-substituted benzim?idazoles via triacyloxyborane intermediates is reported. The mild protocol is efficient and tolerant of acid-labile functional groups. Georg Thieme Verlag Stuttgart - New York.

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