6943-48-2

Upstream product

• 75-31-0 isopropylamine 
• 106-96-7 propargyl bromide 
• 624-65-7 2-propynyl chloride 
• 58351-62-5 N-(2-chloroallyl)-N-isopropylamine 
• 122279-54-3 N-(2-bromoallyl)-N-isopropylamine 

Downstream Products

• 1058164-66-1 1-(2,4-dichlorophenyl)-5-(5-(3-(isopropylamino)prop-1-ynyl)thiophen-2-yl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide 
• 34282-67-2 N-Isopropyl-2-(isopropyl-prop-2-ynyl-amino)-N-phenyl-2-thioxo-acetamide 

Relevant academic research and scientific papers

Efficient Conversion of Tertiary Propargylamides into Imidazoles via Hydroamination-Cyclization

A method to convert tertiary N -propargylamides into 1,2,4-trisubstituted imidazoles using ammonium chloride and zinc triflate as the catalyst is reported. The method is convenient, practical and employs conventional heating. It is also applicable to N -propargyl lactams and tends to populate the so-called 'lead-like' chemistry space.

Aliphatic propargylamines as cellular rescue agents

The present invention relates to the use of a group of propargylamines of the general formula (I) STR1 wherein R1 is hydrogen or CH3 and R2 is (CH2)n CH3 and n is an integer from 0 to 16, and salts thereof, as cellular rescue agents in the treatment and prevention of diseases in which cell death occurs by apoptosis. Some of the compounds of formula I are novel. The invention is also directed to the use of these compounds in the treatment of these diseases, as well as to processes for the preparation of the compounds.

"Vinylogs" and "acetylenylogs" of β-adrenergic agents

Vinylogous (Groups III and V) and acetylenologous (Group IV) analogs of the classical β-adrenergic agents - stimulants and blockers - were prepared in order to evaluate the effect of degree of saturation, position of unsaturation and rigidity of the chain

Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives

The invention provides a new and efficient process for preparing 2,4(5)-substituted or 1,2,4-substituted imidazole derivatives. The invention also provides a process for preparing substituted aminoalkylimidazole derivatives, useful for the treatment of mammals having a variety of disease states, including stroke, epilepsy, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, and the like. The invention also relates to novel aminoalkylimidazole compounds.

N-Substituted Lithium 2-Lithioallylamines: New Intermediates in Synthesis

N-Phenyl or N-benzoyl 2-halogenoallylamines (5) or (10) react successively with phenyl-lithium and lithium naphthalenide at -78 deg C to give the intermediates (4) or (11), which on reaction with electrophiles (water, deuterium oxide, dimethyl disulphide, aldehydes, ketones, or allyl bromide) yield functionalized allyl amines (6) and (12).The corresponding N-alkyl derivatives (9) afford prop-2-ynylamines (8) under the same reaction conditions.