69433-27-8

Usage

Chemical structure

Contains a phenyl ring and a morpholine ring

Type of compound

Ketone derivative

Known as

4-Morpholinophenacylphenyl ketone

Biological activities

Exhibits antifungal and antifibrotic activities

Potential use

Treatment of various diseases and conditions

Application

Used as a building block in the synthesis of other pharmacologically active compounds

Field of interest

Medicinal chemistry and pharmaceutical research

Upstream product

• 92-53-5 4-Phenylmorpholine 
• 103-80-0 phenylacetyl chloride 
• 62673-31-8 benzyl(bromo)zinc 

Downstream Products

• 1283117-65-6 4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-(4-morpholinophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 121111-86-2 1-(4-N-Morpholinophenyl)-2-phenyl-butan-1-one 

Relevant academic research and scientific papers

Nickel-Catalyzed Alkylation of Amide Derivatives

We report the catalytic alkylation of amide derivatives, which relies on the use of nonprecious metal catalysis. Amide derivatives are treated with organozinc reagents, utilizing nickel catalysis, to yield ketone products. The methodology is performed at ambient temperature and is tolerant of variation in both coupling partners. A precursor to a nanomolar glucagon receptor modulator was synthesized using the methodology, underscoring the mild nature of this chemistry and its potential utility in pharmaceutical synthesis. These studies are expected to further promote the use of amides as synthetic building blocks.

NOVEL DIHYDROPYRIMIDIN-2(1H)-ONE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.