69438-16-0

Usage

Structure

Heterocyclic amine derivative with a benzothiophene core structure and a carboxamide functional group

Application

Pharmaceutical industry, drug candidate for neurological disorders, inflammation, and cancer

Potential

Promising candidate for further research and development in medicinal chemistry

Upstream product

• 17722-17-7 N-(4-chlorophenyl)-2-cyanoacetamide 
• 108-94-1 cyclohexanone 
• 89733-19-7 N-(4-Chloro-phenyl)-2-cyano-2-cyclohexylidene-acetamide 

Downstream Products

• 83822-30-4 3-(4-Chloro-phenyl)-5,6,7,8-tetrahydro-3H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one 
• 85930-52-5 N-[3-(4-Chloro-phenylcarbamoyl)-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl]-malonamic acid ethyl ester 
• 1246527-93-4 3-N-(4-chlorophenyl)-4,5-tetramethylene thieno-[2,3-d][1,2,3]-triazin-4(3H)-one 
• 85919-07-9 N-[3-(4-Chloro-phenylcarbamoyl)-4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl]-oxalamic acid ethyl ester 

Relevant academic research and scientific papers

Barium aluminate nano-powders efficient catalyst for the synthesis of novel benzo[b]thiophene, thieno[2,3-c]thiopyran and thieno[2,3-c]pyridine derivatives

Uniform nanopowders of barium aluminate (BaAl2O4) can be synthesized by a facile solution reaction at room temperature using barium and aluminum salts and 2-aminoethanol as a precipitating agent. The asprepared sample showed a good reactivity in the synthesis of benzo[b]thiophene, thieno[2,3-c]thiopyran and thieno[2,3-c]pyridine derivatives. Comparatively the method is efficient and eco-friendly, and finally, a range of compounds with variable functionalities in excellent yield can be achieved.

New approaches for the synthesis of thiophene derivatives with antitumor activities

TETRAHYDROBENZO[B]THIOPHENE derivatives 3a,b and 5a,b were synthesized followed by the alkylation of some derivatives. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was recorded. Some of the synthesized compounds show high inhibitory effects.

Synthesis of some 3-substituted amino-4,5-tetramethylene thieno[2,3-d][ 1,2,3]-triazin-4(3H)-ones as potential antimicrobial agents

A series of 3-Substituted amino-4,5-tetramethylene thieno[2,3-d] [1,2,3]-triazine-4(3H)-ones have been synthesized and characterized by UV,IR, 1H NMR, elemental and mass spectral analysis. The title compounds were evaluated for their antimicrobial activit

2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers

Three series of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene and 2-amino-5,6,7,8-tetrahydrocyclohepta[b]thiophenes with 3-carboxylates and carboxamides have been prepared using the Gewald synthesis and evaluated as A1AR allosteric enhancers. The