6944-27-0

Basic information

• Product Name: 2,2-diphenylethyl 4-methylbenzenesulfonate
• CAS NO: 6944-27-0
• Molecular Formula: C₂₁H₂₀O₃S
• Molecular Weight: 352.4467
• Mol File: 6944-27-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 516.9°C at 760 mmHg
• Flash Point: 266.4°C
• Density: 1.195g/cm³
• Vapor Pressure: 2.8E-10mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: 2,2-diphenylethyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diphenylethyl 4-methylbenzenesulfonate(6944-27-0)
• EPA Substance Registry System: 2,2-diphenylethyl 4-methylbenzenesulfonate(6944-27-0)

Safety Data

• Hazardous Substances Data: 6944-27-0(Hazardous Substances Data)

Usage

General Description

2,2-diphenylethyl 4-methylbenzenesulfonate is a chemical compound with the molecular formula C20H20O3S. It consists of a 2,2-diphenylethyl group (also known as benzoin) attached to a 4-methylbenzenesulfonate group. 2,2-diphenylethyl 4-methylbenzenesulfonate is commonly used as a synthetic intermediate and building block for the production of various organic compounds. It can be employed in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. Additionally, it may also be used as a reagent in organic chemistry reactions. This chemical is important for the production of a wide range of products and plays a role in various industries.

Upstream product

• 3469-00-9 methyl 2,2-diphenylacetate 
• 117-34-0 2,2-diphenylacetic acid 
• 1883-32-5 2,2-diphenyl ethanol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 612-00-0 1,1'-ethylidenebis-benzene 
• 1883-32-5 2,2-diphenyl ethanol 
• 55156-08-6 (-)-(S)-2-Carbethoxy-2-methyl-4,4-diphenylbuttersaeure 
• 55156-10-0 (R)-2-Amino-2-methyl-4,4-diphenyl-butyric acid ethyl ester 
• 55124-28-2 2-Amino-2-methyl-4,4-diphenyl-butyric acid ethyl ester 
• 55124-30-6 2-Isocyanato-2-methyl-4,4-diphenyl-butyric acid ethyl ester 
• 55124-31-7 2-Amino-2-methyl-4,4-diphenyl-butyric acid 
• 55124-22-6 2-Amino-2-methyl-4,4-diphenyl-1-butanol 
• 55156-09-7 (S)-2-Azidocarbonyl-2-methyl-4,4-diphenyl-butyric acid ethyl ester 
• 55124-27-1 2-Azidocarbonyl-2-methyl-4,4-diphenyl-butyric acid ethyl ester 
• 55124-26-0 2-(2,2-Diphenyl-ethyl)-2-methyl-malonic acid monoethyl ester 
• 6887-96-3 1-(4,4-diphenylbutyl)piperazine 
• 41298-46-8 1-(2,2-diphenylethyl)piperazine 
• 56740-71-7 4,4-diphenyl-1-butanol 

Relevant articles and documents

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions

A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.

New 1,3-dioxolane and 1,3-dioxane derivatives as effective modulators to overcome multidrug resistance

Multidrug resistance (MDR) to antitumor agents represents a major obstacle to a successful chemotherapy of cancer. Overexpression of P-glycoprotein (p-gp) seems to be the major factor responsible for MDR. A large number of chemically unrelated compounds are known to interact with p-gp resulting in a decreasing resistance. In our efforts related to structure-activity studies of new potential MDR reversal agents we synthesized a series of compounds that differ in the aromatic core structure, the linker, and the basic moiety. For our search of new aromatic core structures we synthesized novel 2,2-diphenyl-1,3-dioxolane, 2,2- diphenyl-1,3-dioxane, and 4,5-diphenyl-1,3-dioxolane derivatives. A range of lipophilic linker structures and protonable basic moieties were synthesized and investigated to optimize the structure of the potential MDR-modulators. The compounds were tested in vitro using human Caco-2 cells. Both the cytotoxicity of the synthons and their ability to resensitize the cells were determined with a MTT assay. The results show that at low concentration various substances reverse tumor cell MDR. Some of the new structures show better effects than established modulators like trifluoperazine.