694475-70-2

Upstream product

• 51731-17-0 trans-4-methoxy-3-buten-2-one 
• 53341-66-5 ethyl 3-oxo-3-(phenylamino)propionate 
• 5436-21-5 acetylacetaldehyde dimethyl acetal 
• 621-03-4 cyanoacetanilide 
• 945898-86-2 1,2-dihydro-6-methyl-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester 
• 694475-68-8 6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carbonitrile 

Downstream Products

• 1206801-39-9 tert-butyl 5-(2-fluoro-4-(6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamido)phenoxy)-1H-indazol-6-ylcarbamate 
• 945898-87-3 ethyl 5-bromo-6-(bromomethyl)-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxylate 

Relevant academic research and scientific papers

THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

A thienopyridine derivative compound represented by Formula 1 or pharmaceutically acceptable salts thereof have an excellent inhibitory effect on protein kinase activity, and accordingly, pharmaceutical compositions comprising same can be usefully used for the prevention or treatment of a disease associated with the activity of a protein kinase.

THIENOPYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Since a thienopyridine derivative compound represented by chemical formula 1 or a pharmaceutically acceptable salt thereof of the present invention has an excellent effect of inhibiting protein kinase activity, a pharmaceutical composition comprising the same can be usefully used for preventing or treating diseases related to protein kinase activity.COPYRIGHT KIPO 2020

QUINOLINE DERIVATIVE

This compound represented by general formula (I) and having a quinoline skeleton has a strong Axl inhibitory activity. Consequently, this compound can be a therapeutic agent for Axl-related diseases, for example, cancers such as acute myeloid leukemia, chronic myeloid leukemia, melanoma, breast cancer, pancreatic cancer and glioma, kidney diseases, immune system diseases and cardiovascular diseases.

PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS

This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Pyranodipyridine Compound

Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof:

AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET

The present invention provides amidophenoxyindazole compounds useful in the treatment of cancer.

PYRIDONE DERIVATIVE AND HERBICIDE

[Object] To provide a pyridone derivative or an agriculturally acceptable salt thereof which enables control of various weeds growing in upland fields, orchards, paddy fields, and non-crop lands while showing a high safety to useful plants, useful crops,

2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE

There are provided novel compounds of formula (I) wherein R?1?, R?4?, R?5?, G?1?, G?2?, X, L, Y?1?, Y?2? and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.