694502-47-1Relevant academic research and scientific papers
Chemistry of polyhalogenated nitrobutadienes, 6: A new ring-closure approach to perfunctionalized 5-nitropyrimidines
Zapol'skii, Viktor A.,Namyslo, Jan C.,Altug, Cevher,Gjikaj, Mimoza,Kaufmann, Dieter E.
, p. 304 - 310 (2008/12/21)
The recently reported capability of pentachloro-2-nitrobutadiene and some closely related derivatives to allow the synthesis of highly substituted acyclic as well as five-membered (hetero)cyclic compounds is herein extended to pyrimidines with an exceptional substitution pattern. Our novel approach starts from a 1,1-diamino-3,4,4-trichloro-2-nitrobuta-1,3-diene and an appropriate amidine. Some of the resulting perfunctionalized pyrimidines were subjected to further transformations to give promising candidates with respect to biological, especially pharmacological, activity. Georg Thieme Verlag Stuttgart.
