694533-86-3Relevant articles and documents
π-Delocalized β-carbolinium cations as potential antimalarials
Takasu, Kiyosei,Shimogama, Tsubasa,Saiin, Chalerm,Kim, Hye-Sook,Wataya, Yusuke,Ihara, Masataka
, p. 1689 - 1692 (2004)
Several β-carboline compounds including natural products and their corresponding salts were synthesized and evaluated for antimalarial activity and cytotoxicity levels. Quaternary carbolinium cations showed much higher potencies than neutral β-carbolines
Synthesis and evaluation of β-carbolinium cations as new antimalarial agents based on π-delocalized lipophilic cation (DLC) hypothesis
Takasu, Kiyosei,Shimogama, Tsubasa,Saiin, Chalerm,Kim, Hye-Sook,Wataya, Yusuke,Brun, Reto,Ihara, Masataka
, p. 653 - 661 (2007/10/03)
Several β-carbolines including naturally occurring substances and their corresponding cationic derivatives were synthesized and evaluated for antimalarial (antiplasmodial) activity in vitro and in vivo. A tetracyclic carbolinium salt was elucidated for antileishmanial and antitrypanosomal activities in vitro as well as antiplasmodial activity. Quarternary carbolinium cations showed much higher potencies in vitro than electronically neutral β-carbolines and a good correlation was observed between π-delocalized lipophilic cationic (DLC) structure and antimalarial efficacy. β-Carbolinium compounds exhibit medium suppressive activity in vivo against rodent malaria.
