6947-73-5

Usage

Molecular structure

1-[4-(propan-2-yl)benzyl]piperidine consists of a piperidine ring linked to a benzyl group, which is further linked to a propan-2-yl group.

Type of compound

It is a piperidine derivative, which are often used as building blocks in the synthesis of various pharmaceuticals and agrochemicals.

Propan-2-yl group

Also known as isopropyl, it is a common chemical group found in many organic compounds.

Benzyl group

Commonly used as a protective group in organic synthesis and is also found in a variety of natural and synthetic compounds.

Versatility

1-[4-(propan-2-yl)benzyl]piperidine is a versatile compound that can be utilized in various chemical reactions.

Potential applications

It has potential applications in the pharmaceutical and agrochemical industries due to its unique structure and properties.

Upstream product

• 110-89-4 piperidine 
• 50-00-0 formaldehyd 
• 586-61-8 4-iso-propylbromobenzene 
• 536-60-7 cuminol 

Relevant academic research and scientific papers

Half-sandwich ruthenium-carbene catalysts: Synthesis, characterization, and catalytic application in the N-alkylation of amines with alcohols

In this study, the synthesis and characterization of new half-sandwich ruthenium complexes containing oxygen functionalised N-aryl and N-alkyl benzimidazol-2-ylidene ligands have been reported. All ruthenium complexes were tested as catalysts for a wide range of substrates in the N-alkylation of secondary cyclic amines such as pyrrolidine and piperidine, and 4-methylaniline which was a primary aromatic amine with alcohols by hydrogen-borrowing process. The catalytic reactions were performed with 1 mol% catalyst loading at 120 °C, 16 h under solvent-free conditions. All ruthenium complexes showed excellent catalytic activity, and N-alkylated products were obtained selectively.

An expedient three-component synthesis of tertiary benzylamines

A Mannich-like zinc-mediated three-component reaction of aromatic halides, amines, and paraformaldehyde is described. This procedure, which involves the in situ formation of arylzinc reagents, allows the straightforward synthesis of a range of functionalized tertiary benzylamines. Georg Thieme Verlag Stuttgart.

Three-component synthesis of α-branched amines under barbier-like conditions

(Chemical Equation Presented) An array of α-branched amines has been prepared by using an expedient three-component Mannich-type reaction among organic halides, aldehyde derivatives, and amines. The experimental procedure, which is characterized by its simplicity, employs zinc dust for the in situ generation of organozinc reagents. We show that this Barbier-like protocol constitutes a useful entry to diarylmethylamines, 1,2-diarylethylamines, α- or β-amino esters, benzylamines, and β-arylethylamines.