6947-84-8

Basic information

• Product Name: 2-{2-[(6-methoxyquinolin-8-yl)amino]ethyl}-1H-isoindole-1,3(2H)-dione
• CAS NO: 6947-84-8
• Molecular Formula: C₂₀H₁₇N₃O₃
• Molecular Weight: 347.3673
• Mol File: 6947-84-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 581.7°C at 760 mmHg
• Flash Point: 305.6°C
• Density: 1.36g/cm³
• Vapor Pressure: 1.6E-13mmHg at 25°C
• Refractive Index: 1.7
• CAS DataBase Reference: 2-{2-[(6-methoxyquinolin-8-yl)amino]ethyl}-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{2-[(6-methoxyquinolin-8-yl)amino]ethyl}-1H-isoindole-1,3(2H)-dione(6947-84-8)
• EPA Substance Registry System: 2-{2-[(6-methoxyquinolin-8-yl)amino]ethyl}-1H-isoindole-1,3(2H)-dione(6947-84-8)

Safety Data

• Hazardous Substances Data: 6947-84-8(Hazardous Substances Data)

Usage

Family

isoindole-1,3-dione

Quinoline ring

contains a methoxy group attached to the 6th position

Aminoethyl group

connected to the 2nd position of the quinoline ring

Fused isoindole ring

includes a dione functional group

Potential pharmaceutical or biological activities

due to its unique structure, further research could explore its applications.

Upstream product

• 90-52-8 6-methoxyquinolin-8-amine 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 96-96-8 4-methoxy-2-nitroaniline 
• 4280-28-8 3,4-dinitroanisole 
• 85-81-4 6-methoxy-8-nitroquinoline 

Relevant articles and documents

Novel squaramides with in vitro liver stage antiplasmodial activity

A structure-activity relationship study was performed with ten 8-aminoquinoline-squaramides compounds active against liver stage malaria parasites, using human hepatoma cells (Huh7) infected by Plasmodium berghei parasites. In addition, their blood-schizontocidal activity was assessed against chloroquine-resistant W2 strain Plasmodium falciparum. Compound 3 was 7.3-fold more potent than the positive control primaquine against liver-stage parasites, illustrating the importance of the squarate moiety to activity.