69479-11-4Relevant academic research and scientific papers
Synthesis and pharmacological studies of N-substituted 6-[(2- aminoethyl)amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinediones, novel class III antiarrhythmic agents
Katakami,Yokoyama,Miyamoto,Mori,Kawauchi,Nobori,San-nohe,Kaiho,Kamiya
, p. 3325 - 3330 (2007/10/02)
A series of 6-[(2-aminoethyl)amino]-1,3-dimethyl-2,4(1H,3H)- pyrimidinedione derivatives were synthesized and studied for their class III electrophysiological activity and class II (β-blocking) effects in in vitro and in vivo models. Structure-activity re
N-ARYLOXYPROPYL-N'-DIOXOPYRIMIDYL-ALPHA,OMEGA-ALKYLENEDIAMINES
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, (2008/06/13)
Physiologically-acceptable substituted 1,2-ethylenediamines and 1,3-propylenediamines, in free-base and in acid-addition-salt form, have highly pronounced and cardioselective β-adrenolytic action, antiarrhythmic action and hypotensive action on administra
