69481-44-3Relevant academic research and scientific papers
FLUORO-KETONES VI. SYNTHESIS OF PERFLUORO DI- AND TETRA-KETONES FROM 1,1-DICHLOROBENZYLLITHIUM AND PERFLUOROESTERS
Chen, Loomis S.,Tamborski, Christ
, p. 269 - 280 (2007/10/02)
The reaction of C6H5CCl2Li with perfluorinated mono and diesters yields fluorochloroketones in high yield.Hydrolysis of such compounds produces alpha-beta fluorinated di- and tetra-ketones, respectively.Various hydrates of the fluorinated ketones have bee
SYNTHESIS OF FLUORINATED α-DIKETONES AND SOME INTERMEDIATES
Hudlicky, M.
, p. 383 - 406 (2007/10/02)
Reactions of perfluoroalkylcopper compounds with α-ketoacyl chlorides were used for the synthesis of fluorinated α-diketones.Heptafluoropropylcopper prepared from copper bronze and 1-iodoheptafluoropropane reacted with benzoylformyl chloride to give heptafluoro-1-phenyl-1,2-pentanedione, with trimethylpyruvyl chloride to give 2,2-dimethyl-5,5,6,6,7,7,7-heptafluoro-3,4-heptanedione, and with 3,3,4,4,5,5,5-heptafluoro-2-keto-pentanoyl chloride or oxalyl chloride to give tetradecafluoro-4,5-octane-dione.Syntheses of fluorinated acetylenes, cyanohydrins, α-hydroxy acids, α-keto acids, their chlorides, and other intermediates for the syntheses of α-diketones by the above route and by other methods are described.An interesting seven-membered ring containing β-hydroxy ketone was obtained by an intramolecular aldol condensation of a fluorinated bis(methyl) ketone.
