6949-34-4Relevant academic research and scientific papers
A dual-channel colorimetric and ratiometric fluorescence chemosensor for detection of Hg2+ ion and its bioimaging applications
Ravichandiran, Palanisamy,Kaliannagounder, Vignesh Krishnamoorthi,Maroli, Nikhil,Boguszewska-Czubara, Anna,Mas?yk, Maciej,Kim, Ae Rhan,Park, Byung-Hyun,Han, Myung-Kwan,Kim, Cheol Sang,Park, Chan Hee,Yoo, Dong Jin
, (2021)
A new colorimetric and ratiometric fluorescence chemosensor 4-((3-(octadecylthio)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide (4DBS) was synthesized and investigated for the selective detection of Hg2+ in DMSO-H2O (
Simple Colorimetric and Fluorescence Chemosensing Probe for Selective Detection of Sn2+Ions in an Aqueous Solution: Evaluation of the Novel Sensing Mechanism and Its Bioimaging Applications
Bella, Antony Paulraj,Boguszewska-Czubara, Anna,Han, Myung-Kwan,Johnson, Princy Merlin,Kaliannagounder, Vignesh Krishnamoorthi,Kim, Ae Rhan,Kim, Cheol Sang,Mas?yk, Maciej,Park, Byung-Hyun,Park, Chan Hee,Ravichandiran, Palanisamy,Yoo, Dong Jin
, p. 801 - 811 (2021)
An easily accessible colorimetric and fluorescence probe 4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide (4CBS) was successfully developed for the selective and sensitive detection of Sn2+ in an aqueous solution. The sensing mec
Synthesis and in Vitro Biological Evaluation of Aminonaphthoquinones and Benzo[ b ]phenazine-6,11-dione Derivatives as Potential Antibacterial and Antifungal Compounds
Tuyun, Ama? Fatih,Bayrak, Nilüfer,Yldrm, Hatice,Onul, Nihal,Mataraci Kara, Emel,Ozbek Celik, Berna
, (2015/07/15)
A series of 2-arylamino-3-chloro-1,4-naphthoquinone derivatives (3a-h) by the reaction of 2,3-dichloro-1,4-naphthoquinone with aryl amines (2a-h) and benzo[b]phenazine-6,11-dione derivatives (4a-c) by the treatment of 2-arylamino-3-chloro-1,4-naphthoquino
Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors
Lawrence, Harshani R.,Kazi, Aslamuzzaman,Luo, Yunting,Kendig, Robert,Ge, Yiyu,Jain, Sanjula,Daniel, Kenyon,Santiago, Daniel,Guida, Wayne C.,Sebti, Said M.
experimental part, p. 5576 - 5592 (2010/09/15)
Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.
