69491-56-1

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyrimidin-2-ylaniline is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activities. It has been studied for its antitumor properties, making it a valuable component in the development of cancer treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Pyrimidin-2-ylaniline is utilized as a building block in the creation of agrochemicals. Its role as a tyrosine kinase inhibitor suggests it may have applications in developing products that can manage or control the growth of certain organisms, contributing to agricultural advancements.
Further research is necessary to fully explore and understand the comprehensive applications and properties of 3-Pyrimidin-2-ylaniline, as its potential impact spans across different fields of science and medicine.

InChI:InChI=1/C10H9N3/c11-9-4-1-3-8(7-9)10-12-5-2-6-13-10/h1-7H,11H2

Upstream product

• 77139-57-2 5-chloro-2-m-nitrophenylpyrimidine 
• 56406-50-9 3-nitrobenzamidine hydrochloride 
• 30418-59-8 3-Aminophenylboronic acid 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 1439909-31-5 tert-butyl ((1S,2S)-2-((5-cyano-4-((3-(pyrimidin-2-yl)phenyl)amino)pyrimidin-2-yl)amino)-3,3-difluorocyclohexyl)carbamate 
• 1438419-30-7 5-((1R,2S)-2-aminocyclohexylamino)-3-(3-(pyrimidin-2-yl)phenylamino)pyrazine-2-carboxamide 
• 1438423-77-8 5-((1R,2S)-2-aminocyclohexylamino)-3-(3-(pyrimidin-2-yl)phenylamino)pyrazine-2-carbonitrile 
• 1438424-32-8 tert-butyl (1S,2R)-2-(5-cyano-6-(3-(pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)cyclohexylcarbamate 
• 1438424-45-3 (R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate 
• 1438423-82-5 5-((1R,2R)-2-amino-3,3-difluorocyclohexylamino)-3-(3-(pyrimidin-2-yl)phenylamino)pyrazine-2-carbonitrile 
• 1374157-64-8 (R)-2-(1-amino-4-methyl-1-oxopentan-2-ylamino)-6-oxo-4-(3-(pyrimidin-2-yl)phenylamino)-1,6-dihydropyrimidine-5-carboxamide 
• 1374157-70-6 (R)-2-(5-cyano-4-methoxy-6-(3-(pyrimidin-2-yl)phenylamino)pyrimidin-2-ylamino)-4-methylpentamide. 
• 1374157-68-2 4-methoxy-2-(methylthio)-6-(3-(pyrimidin-2-yl)phenylamino)pyrimidine-5-carbonitrile 
• 1374157-66-0 4-chloro-2-(methylthio)-6-(3-(pyrimidin-2-yl)phenylamino)pyrimidine-5-carbonitrile 
• 69491-52-7 2-(3-nitrophenyl)pyrimidine 

Relevant academic research and scientific papers

Copper mediated C-H amination with oximes: En route to primary anilines

Here we report an efficient Cu(i)-mediated C-H amination reaction with oximes as amino donors to introduce NH2 groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonstrated in a late-stage modification of telmisartan (an antagonist for the angiotensin II receptor).

BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS

The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.