695-56-7Relevant academic research and scientific papers
Preparation of Cyclobutene Acetals and Tricyclic Oxetanes through Photochemical Tandem and Cascade Reactions
Buendia, Julien,Chang, Zong,Eijsberg, Hendrik,Guillot, Régis,Frongia, Angelo,Secci, Francesco,Xie, Juan,Robin, Sylvie,Boddaert, Thomas,Aitken, David J.
, p. 6592 - 6596 (2018)
We describe a photochemical reaction using two starting materials, a cyclopent-2-enone and an alkene, which are transformed in a controlled manner via the initial [2+2]-photocycloaddition adducts into cyclobutene aldehydes (conveniently trapped as stable acetals) or unprecedented angular tricyclic 4:4:4 oxetane-containing skeletons. These compounds are formed through tandem or triple cascade photochemical reaction processes, respectively. Small libraries of each compound class were prepared, thus suggesting that this photochemistry approach opens new opportunities for synthesis design and for widening molecular diversity.
Synthesis of Complex Stereoheptads en Route to Daphnane Diterpene Orthoesters
Nguyen, Long V.,Beeler, Aaron B.
supporting information, p. 5177 - 5180 (2018/09/13)
Tricyclic cores of the daphnane diterpene orthoesters (DDOs) are synthesized in 10 steps from readily available materials. Key to their assembly is the development of a stereocontrolled p-quinol functionalization sequence which enables rapid access to DDO C-ring stereopolyads from simple precursors. Problems encountered in stereo- and regioselectivity are highlighted and solved by exact changes in choreography, although it is shown that the undesired stereochemical outcomes also proceed with high selectivity.
N-amino bicyclic compounds
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, (2008/06/13)
N-amino hexahydrocyclopenta imidazole-2(1H)-one derivatives useful for treating or preventing thrombo-embolic disorders and ocular diseases characterized by increased ocular pressure.
Distannoxane-catalyzed acetilization of carbonyls
Otera, Junzo,Dan-oh, Nobuhisa,Nozaki, Hitosi
, p. 1449 - 1456 (2007/10/02)
1,3-Disubstituted tetrabutyldistannoxanes catalyze acetilization of carbonyl compounds under mild conditions. Thorough investigations of factors influencing this reaction are given. A variety of synthetically useful carbonyl compounds are efficiently converted to acetals. In particular, acetilization of cyclic α,β-unsaturated ketones is readily achieved which have met with only limited success so far.
