69504-08-1

Upstream product

• 86529-09-1 N-(9-((2R,3R,4R,5R)-3,4-bis((tert-butyldimethylsilyl)oxy)-5-(((tertbutyldimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 79974-68-8 N⁶-benzoyl-2',3'-bis-O-<(1,1-dimethylethyl)dimethylsilyl>adenosine 
• 88121-45-3 6-N-benzoyl-3',5'-bis-O-tert-butyldimethylsilyladenosine 

Downstream Products

• 140210-73-7 Sodium adenosine 2',5'-bis(ethylphosphate) 
• 140210-72-6 6-N-Benzoyl-3'-O-t-butyldimethylsilyladenosine 2',5'-bis(O-(2-cyanoethyl)-O-ethylphosphate) 

Relevant academic research and scientific papers

Aqueous trichloroacetic acid: Another useful reagent for highly selective 5′-desilylation of multisilylated nucleosides

Highly selective 5′-desilylation of multisilylated nucleosides can be achieved in excellent yield by treatment with 4.2 M aqueous trichloroacetic acid:THF (1:4) at 0°C.

Facile and highly selective 5′-desilylation of multisilylated nucleosides

The facile and highly selective 5′-desilylation of multisilylated nucleosides was discussed. The selective 5′-desilylation using aqueous acetic acid can be improved if THF is added as a co-solvent. It was found that the use of THF increases the solubility