695215-94-2Relevant articles and documents
Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases
Liu, Yanxia,Zhang, Wei,Li, Li,Salvador, Lilibeth A.,Chen, Tiantian,Chen, Wuyan,Felsenstein, Kevin M.,Ladd, Thomas B.,Price, Ashleigh R.,Golde, Todd E.,He, Jianhua,Xu, Yechun,Li, Yingxia,Luesch, Hendrik
supporting information, p. 10749 - 10765 (2013/02/23)
Inspired by marine cyanobacterial natural products, we synthesized modified peptides with a central statine-core unit, characteristic for aspartic protease inhibition. A series of tasiamide B analogues inhibited BACE1, a therapeutic target in Alzheimer's
COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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Page/Page column 63, (2010/06/19)
The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.
ASPARTYL PROTEASE INHIBITORS
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Page/Page column 52, (2009/01/20)
The invention provides compounds of the formula (I) N-oxides, addition salts, quaternary amines, metal complexes, stereochemically isomeric forms and metabolites thereof, wherein G is-O-, -S(=O)r-, -CRdRd or -NRa-; W is H, C1-C6