695231-61-9Relevant academic research and scientific papers
Stereoselective ligand-exchange reaction of planar-chiral cyclopentadienyl-ruthenium complexes: Thermodynamic control of configuration at a stereogenic metal center
Matsushima, Yuji,Onitsuka, Kiyotaka,Takahashi, Shigetoshi
, p. 547 - 553 (2004)
The reaction of planar-chiral cyclopentadienyl-ruthenium complexes with Bu4NI resulted in the formation of lodo complexes with high diastereoselectivity (up to >99%de). The stereochemistry of the ruthenium center in the starting material did not influence the diastereoselectivity of the products. Epimerization of a diastereomerically pure sample gave a mixture of two diastereomers in the same ratio as with the ligand-exchange reaction, suggesting that the selectivity is determined by the difference in thermodynamic stability between the diastereomeric pair of iodo complexes. The ratio of the products depends on the nature of the substituent on the cyclopentadienyl ring and P ligands on the ruthenium atom. A combination of small substituents on the cyclopentadienyl group and small P ligands with strong electron-donating ability favored the formation of 2-1. The bulkiness of the substituents on the cyclopentadienyl group or of the P ligands, and low electron-donating ability of the P ligands increased the ratio of 2-II complexes to 2-I isomer.
