6953-67-9

Basic information

• Product Name: 1-(3,4-dimethoxyphenyl)prop-2-yn-1-ol
• Synonyms: 1-(3,4-Dimethoxyphenyl)-2-propyn-1-ol
• CAS NO: 6953-67-9
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.2112
• Mol File: 6953-67-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 296.3°C at 760 mmHg
• Flash Point: 133°C
• Density: 1.138g/cm³
• Vapor Pressure: 0.000651mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 1-(3,4-dimethoxyphenyl)prop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxyphenyl)prop-2-yn-1-ol(6953-67-9)
• EPA Substance Registry System: 1-(3,4-dimethoxyphenyl)prop-2-yn-1-ol(6953-67-9)

Safety Data

• Hazardous Substances Data: 6953-67-9(Hazardous Substances Data)

Usage

General Description

1-(3,4-dimethoxyphenyl)prop-2-yn-1-ol is a chemical compound with the molecular formula C11H14O3. It is a propargyl alcohol derivative with a phenyl group substituted with two methoxy groups at the 3 and 4 positions. 1-(3,4-dimethoxyphenyl)prop-2-yn-1-ol is commonly used as a reactant in organic synthesis, particularly in the formation of heterocycles and other complex organic molecules. It is also known for its biologically active properties, including potential antioxidant and anti-inflammatory effects. The compound's unique structure and reactivity make it valuable in the development of new pharmaceuticals and chemical products.

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 4301-14-8 acetylenemagnesium bromide 
• 70277-75-7 lithium acetylide 
• 74-86-2 acetylene 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 16854-95-8 2-(3,4-dimethoxy-phenyl)-6-methyl-2H-chromene 
• 121507-58-2 1,2-Dimethoxy-4-(1-p-tolyloxy-prop-2-ynyl)-benzene 
• 10548-83-1 1-(3,4-dimethoxyphenyl)propan-1-ol 
• 4497-40-9 3,4-dimethoxy-cinnamaldehyde 
• 34239-56-0 1-(3,4-dimethoxyphenyl)prop-2-yn-1-one 
• 58045-88-8 3,4-dimethoxycinnamaldehyde 

Relevant articles and documents

Lipase/Oxovanadium Co-Catalyzed Dynamic Kinetic Resolution of Propargyl Alcohols: Competition between Racemization and Rearrangement

Quantitative conversion of racemic propargyl alcohols into optically active propargyl esters with up to 99% ee has been achieved by lipase/oxovanadium co-catalyzed dynamic kinetic resolution, which combines the lipase-catalyzed enantioselective esterification of the racemic substrates and the in situ racemization of the remaining enantiomers. The success is owed to our discovery of a magic solvent, (trifluoromethyl)benzene, that accelerated the racemization while sufficiently suppressing the common oxovanadium-catalyzed rearrangement of propargyl alcohols to irreversibly produce enals.

Parallel synthesis of "Click" chalcones as antitubulin agents

It has been shown that some chalcones are able to inhibit tubulin polymerization, giving cytotoxicity and destruction of tumoral vasculature. A library of 180 novel chalcone analogs has been synthesized via click chemistry and screened for their cytotoxic

Rapid preparation of 3-deoxyanthocyanidins and novel dicationic derivatives: New insight into an old procedure

Common 3-deoxyanthocyanidins and original dicationic flavylium- benzopyrylium derivatives are easily and efficiently synthesized through reactions between the corresponding phenols and aryl ethynyl ketones in the presence of aqueous hexafluorophosphoric acid. The mechanism of the reaction is discussed and two competitive pathways are consistent with our results. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.