6954-53-6Relevant academic research and scientific papers
Rapid synthesis of 4-benzylidene and 4-[bis-(4-methoxyphenyl)-methylene-2-substituted phenyl-benzopyrans as potential selective estrogen receptor modulators (SERMs) using McMurry coupling reaction
Gupta, Atul,Dwivedy, Anila,Keshri, Govind,Sharma, Ramesh,Balapure, Anil Kumar,Singh, Man Mohan,Ray, Suprabhat
, p. 6006 - 6012 (2006)
7-Methoxy-4-(4-methoxybenzylidene)-2-substituted phenyl-benzopyrans I and 4-[bis-(4-methoxyphenyl)-methylene-2-substituted phenyl-benzopyrans II carrying different alkylamino residues, designed as estrogen receptor (ER) binding ligands, were successfully synthesized through the McMurry coupling reaction of substituted benzaldehyde/substituted benzophenones and 2-hydroxyphenyl-7-methoxy-chroman-4-one in presence of lithium aluminum hydride and titanium (IV) chloride (LAH-TiCl4). Self-coupling of carbonyl reactants led to the formation of several side products. The prototypes were evaluated for their relative binding affinity (RBA), as well as their estrogenic and antiestrogenic activities. High order of estrogenic activity (>50% gain) observed with compounds 3, 7a, 7b, 7c, 8, and 10a and also their partial estrogen antagonistic activity (≥15%) at the uterine level points toward successful designing of the compounds. Compounds 4, 7a, 7b, 7c, and 10a also possessed significant anticancer activity against human adenocarcinoma cell line (MCF-7 cell line) that may be related to their estrogen-dependent action.
COLORING COMPOSITION AND RECORDING METHOD
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Paragraph 0093, (2018/03/23)
PROBLEM TO BE SOLVED: To provide a coloring composition that can form an image having silver gloss. SOLUTION: A coloring composition contains a stilbene compound represented by general formula (1), and two or more solvents. For the two or more solvents, a
COLORING COMPOSITION
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Paragraph 0073; 0074; 0081; 0082, (2018/05/24)
PROBLEM TO BE SOLVED: To provide a coloring composition capable of forming images having metallic gloss colors of various colors without precipitation of a luster coloring material. SOLUTION: A coloring composition includes a stilbene-based compound repre
ORGANIC COLORANT HAVING SILVER GLOSS AND COLORING COMPOSITION
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Paragraph 0036; 0041, (2017/12/01)
PROBLEM TO BE SOLVED: To provide an organic colorant having a silver gloss. SOLUTION: An organic colorant having a silver gloss comprises a stilbene compound represented by the following formula. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
