6954-98-9

Usage

Structure

piperazine derivative with a hydroxyl group attached to the propan-1-ol moiety

Biological activity

Potent and selective serotonin 5-HT3 receptor antagonist

Function

Blocks the action of serotonin at the 5-HT3 receptor

Receptor location

Found in the central and peripheral nervous systems

Physiological processes affected

Neurotransmission and gastrointestinal function

Potential applications

Treatment of conditions such as emesis, irritable bowel syndrome, and anxiety.

Upstream product

• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 627-18-9 1-bromo-3-propanol 

Downstream Products

• 141473-54-3 4-(3-Trifluoromethylphenyl)-1-[3-(3,4-ethylenedioxyphenylcarbamoyloxy)propyl]piperazine, hydrochloride 
• 141473-85-0 4-(4-Chlorophenyl)-1-[3-(3,4,5-trimethoxyphenylcarbamoyloxy)propyl]piperazine 
• 1262048-31-6 3-[4-(4-chlorophenyl)piperazin-1-yl]propyl methanesulfonate 
• 141473-52-1 4-(4-Chlorophenyl)-1-[3-(3,4,5-trichlorophenylcarbamoyloxy)propyl]piperazine, hydrochloride 
• 141473-83-8 4-(4-Chlorophenyl)-1-[3-(6-benzothiazolylcarbamoyloxy)propyl]piperazine, hydrochloride 
• 141473-77-0 4-(4-Chlorophenyl)-1-[3-(3,4-ethylenedioxyphenylcarbamoyloxy)propyl]piperazine, hydrochloride 
• 141473-56-5 4-(4-Chlorophenyl)-1-(3-[3,4,5-trimethoxyphenyl(thiocarbamoyl)oxy]propyl)piperazine, hydrochloride 

Relevant academic research and scientific papers

Spiro[pyrrolidine-3,3′-oxindoles] as 5-HT7 receptor ligands

Here we report the design and synthesis of spiro[pyrrolidine-3,3′-oxindole] derivatives representing a novel scaffold of 5-HT7 receptor ligands. The synthesized analogues were validated as low nanomolar ligands showing selectivity in a panel of

Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(Pyridin-3-yl)-1H-benzimidazole as new delavirdine analogues

The synthesis of a series of substituted arylpiperazines linked to a 2-(pyridin-3-yl)-1H-benzo[d] imidazole scaffold through an alkylic linker is reported. The novel 1-(2-(4-arylpiperazin-1-yl) alkyl)-2-(pyridin-3-yl)-1H- benzimidazole derivatives are structurally related to the anti-HIV-1 drug Delavirdine and belong to the bis(heteroaryl)piperazines family (BHAPs), a well known HIV-1 reverse transcriptase inhibitors group.