69540-73-4

Basic information

• Product Name: 4-pyrrolidin-1-yl-1,3-dihydro-2H-1,5-benzodiazepine-2-thione
• CAS NO: 69540-73-4
• Molecular Formula: C₁₃H₁₅N₃S
• Molecular Weight: 245.3433
• Mol File: 69540-73-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 396.1°C at 760 mmHg
• Flash Point: 193.4°C
• Density: 1.32g/cm³
• Vapor Pressure: 1.75E-06mmHg at 25°C
• Refractive Index: 1.707
• CAS DataBase Reference: 4-pyrrolidin-1-yl-1,3-dihydro-2H-1,5-benzodiazepine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-pyrrolidin-1-yl-1,3-dihydro-2H-1,5-benzodiazepine-2-thione(69540-73-4)
• EPA Substance Registry System: 4-pyrrolidin-1-yl-1,3-dihydro-2H-1,5-benzodiazepine-2-thione(69540-73-4)

Safety Data

• Hazardous Substances Data: 69540-73-4(Hazardous Substances Data)

Relevant articles and documents

Research on 1,5-benzodiazepines. III.

Treatment of 2,3-dihydro-2-oxo-4-dialkylamino-1H-1,5-benzodiazepines with phosphorus pentasulfide afforded 2-thio derivatives which in turn gave the corresponding methylmercapto derivatives by reaction with sodium hydride and methyl iodide. By treating these compounds with dialkylamines the formation of 2,4-bisdialkylamino-3H-1,5-benzodiazepines was achieved. Pharmacological screening of some of the products indicated that the introduction of a second dialkylamino substituent into the 1,5-benzodiazepine molecule gave the compounds CNS excitant properties, while the initial monodialkylamino derivatives containing sulfur showed a CNS depressant activity.