69543-15-3Relevant articles and documents
Total Synthesis of Penicibilaenes via C-C Activation-Enabled Skeleton Deconstruction and Desaturation Relay-Mediated C-H Functionalization
Xue, Yibin,Dong, Guangbin
supporting information, p. 8272 - 8277 (2021/06/27)
Herein, we describe the first total synthesis of sesquiterpene penicibilaenes A and B through a "C-C/C-H"approach. In the "C-C"stage, the Rh-catalyzed "cut-and-sew"transformation between trisubstituted alkene and cyclobutanone has been employed to constru
Alkyne Aminopalladation/Heck and Suzuki Cascades: An Approach to Tetrasubstituted Enamines
Geffers, Finn J.,Jones, Peter G.,Kurth, Florens R.,Werz, Daniel B.
supporting information, p. 14846 - 14850 (2021/10/19)
Alkyne aminopalladation reactions starting from tosylamides are reported. The emerging vinylic Pd species are converted either in an intramolecular Heck reaction with olefinic units or in an intermolecular Suzuki reaction by using boronic acids exhibiting broad functional group tolerance. Tetra(hetero)substituted tosylated enamines are obtained in a simple one-pot process.
Lithium Chloride Catalyzed Asymmetric Domino Aza-Michael Addition/[3 + 2] Cycloaddition Reactions for the Synthesis of Spiro- and Bicyclic α,β,γ-Triamino Acid Derivatives
Just, David,Hernandez-Guerra, Daniel,Kritsch, Susanne,Pohl, Radek,Císa?ová, Ivana,Jones, Peter G.,Mackman, Richard,Bahador, Gina,Jahn, Ullrich
, p. 5213 - 5221 (2018/09/14)
Angularly and peri-fused tricyclic pyrrolidinopyrazolines are efficiently prepared by LiCl-catalyzed domino aza-Michael addition-1,3-dipolar cycloaddition reactions. The absolute stereochemistry is controlled in the aza-Michael addition step, nonaflyl azide serves as effective diazo transfer reagent to the formed enolate and the resulting diazo dipole engages in the 1,3-dipolar cycloaddition step. The resulting tricyclic pyrrolidinopyrazolines can be easily transformed to enantiomerically enriched nonproteinogenic spirocyclic α,β,γ-triamino acids, angularly or peri-fused tricyclic β-prolines or pyrimidines. The activity of the tricyclic amino acid derivatives against the hepatitis C virus was determined.
