69570-39-4

Usage

Uses

Used in Pharmaceutical Research:
S-(3-chloro-2-methyl-3-oxopropyl) (S)-ethanethioate is used as a chiral building block for the synthesis of various bioactive molecules and pharmaceutical intermediates, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
This chemical compound is also utilized as a building block in the production of various agrochemical compounds, playing a role in the development of agricultural products and pesticides.
It is important to handle S-(3-chloro-2-methyl-3-oxopropyl) (S)-ethanethioate with care and use proper safety precautions, as it can be hazardous if not handled properly.

InChI:InChI=1/C6H9ClO2S/c1-4(6(7)9)3-10-5(2)8/h4H,3H2,1-2H3/t4-/m0/s1

Upstream product

• 76497-39-7 (2S)-3-acetylthio-2-methylpropionic acid 
• 74431-52-0 (R)-3-acetylsulfanyl-2-methyl-propionic acid 

Downstream Products

• 65167-28-4 (2S)-1-((2R)-3-(acetylthio)-2-methylpropanoyl)pyrrolidine-2-carboxylic acid 
• 224626-08-8 (R)-1-((R)-3-Acetylsulfanyl-2-methyl-propionyl)-pyrrolidine-2-carboxylic acid 
• 77708-84-0 N-(3'-Acetylthio-2'-methylpropanoyl)-L-(1,2,3,4-tetrahydroisoquinoline)-3-carboxylic acid 
• 77708-84-0 (S)-2-(3-Acetylsulfanyl-2-methyl-propionyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid 
• 86323-70-8 [((S)-3-Acetylsulfanyl-2-methyl-propionyl)-(3,4-dimethoxy-phenyl)-amino]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers

β-Lactams are the most successful antibacterials, but their effectiveness is threatened by resistance, most importantly by production of serine- and metallo-β-lactamases (MBLs). MBLs are of increasing concern because they catalyze the hydrolysis of almost all β-lactam antibiotics, including recent-generation carbapenems. Clinically useful serine-β-lactamase inhibitors have been developed, but such inhibitors are not available for MBLs. L-Captopril, which is used to treat hypertension via angiotensin-converting enzyme inhibition, has been reported to inhibit MBLs by chelating the active site zinc ions via its thiol(ate). We report systematic studies on B1 MBL inhibition by all four captopril stereoisomers. High-resolution crystal structures of three MBLs (IMP-1, BcII, and VIM-2) in complex with either the L- or D-captopril stereoisomer reveal correlations between the binding mode and inhibition potency. The results will be useful in the design of MBL inhibitors with the breadth of selectivity required for clinical application against carbapenem-resistant Enterobacteriaceae and other organisms causing MBL-mediated resistant infections.

Thiazaspirane derivatives, process for their preparation, and medicaments

Novel thiazaspirane derivatives of the general formula STR1 including salts thereof with physiologically acceptable acids and bases, processes for their preparation and medicaments containing them.

Angiotensin-Converting Enzyme Inhibitors. New Orally Active Antihypertensive (Mercaptoalkanoyl)- and glycine Derivatives

A variety of N-substituted (mercaptoalkanoyl)- and glycine derivatives was synthesized and their ability in inhibiting the activity of angiotensin-converting enzyme (ACE) was examined in vitro and in vivo.The acylthio derivatives prepared are assumed to act as prodrugs since they are much less active than the corresponding free SH compounds in vitro and can be expected to act in vivo only after conversion to the free sulfhydryl compounds.A number of this compounds are potent ACE inhibitors that lowered blood pressure in Na-deficient, conscious spontaneously hypertensive rats (SHR), a high renin model.One of the most active members of the series was (S)-N-cyclopentyl-N--2-methyl-1-oxopropyl>glycine (REV 3659-(S), pivopril).Structure-activity relationships are discussed.