69574-21-6Relevant articles and documents
Optimization of potent and selective quinazolinediones: Inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity
Matharu, Daljit S.,Flaherty, Daniel P.,Simpson, Denise S.,Schroeder, Chad E.,Chung, Donghoon,Yan, Dan,Noah, James W.,Jonsson, Colleen B.,White, E. Lucile,Aubé, Jeffrey,Plemper, Richard K.,Severson, William E.,Golden, Jennifer E.
, p. 10314 - 10328 (2014)
A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability