69581-53-9Relevant academic research and scientific papers
Convenient synthesis of N1-substituted orotic acid derivatives
Bowler, Jeannette T.,Clausen, Caitlin R.,Blackburn, Daniel J.,Wu, Weiming
, p. 6465 - 6466 (2014/12/11)
A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can be readily synthesized.
Maleimide and succinimide derivatives and herbicidal method of use thereof
-
, (2008/06/13)
Compounds of the formulae STR1 are disclosed wherein R is hydrogen, halogen, phenyl, phenyl-C1 to C4 alkylthio, C1 to C6 alkylthio, C5 to C7 cycloalkylthio, phenylthio or phenylsulfonyl; R1 is amino, C5 to C7 cycloalkylamino, C1 to C6 alkylamino, C1 to C4 -alkoxy-substituted-phenyl-(C1 to C4 -alkylamino), phenylamino, naphthylamino, furfurylamino, phenyl-(C1 to C4)-alkylamino, phenylamino-substituted by C1 to C4 alkoxy, halogen or C1 to C4 alkyl or phenylsulfonyl. R2 is hydrogen; and R3 is C1 to C6 alkyl, alkoxy or phenyl. The compounds have herbicidal properties.
THROUGH-SPACE ELECTROSTATIC CONTROL IN A NOVEL REGIOSPECIFIC RING TRANSFORMATION OF 1,3,4-TRISUBSTITUTED MALEIMIDES
Seres, J.,Naray-Szabo, G.,Sinom, K.,Daroczi-Csuka, K.,Szilagyi, I.,Parkanyi, L.
, p. 1565 - 1570 (2007/10/02)
Ring transformation of 1-ethoxycarbonyl-3,4-disubstituted maleimide in alkaline solution yielded exclusively 1,5-disubstituted orotic acid.No hydantoin derivatives were detected.These findings can be best explained by assuming that the initial attack of the hydroxylate anion occurs at C2 and not at C5.X-ray diffraction and quantum chemical investigation indicate that stereospecificity is mainly due to through-space electrostatic effects.
